Abstract Th17-polarized CD4+ effector T-cells together with their immunosuppressive
regulatory T-cell (Treg) counterparts, with transcriptional profiles governed by the lineage …

Metabolic reprogramming is a hallmark of activated T cells. The switch from oxidative
phosphorylation to aerobic glycolysis provides energy and intermediary metabolites for the …

Pellino1 (Peli1) is a highly conserved E3 Ub ligase that exerts its biological functions by
mediating target protein ubiquitination. Extensive evidence has demonstrated the crucial …

Mitochondrial dynamics can regulate Major Histocompatibility Complex (MHC)-I antigen
expression by cancer cells and their immunogenicity in mice and in patients with …

After natalizumab (NAT) cessation, some multiple sclerosis (MS) patients experience a
severe disease rebound. The rebound pathophysiology is still unclear; however, it has been …

Background Psoriasis is a chronically relapsing inflammatory skin disease primarily
perpetuated by skin-resident IL-17–producing T (T17) cells. Pellino-1 (Peli1) belongs to a …

Adaptive immunity relies on specialized effector functions elicited by lymphocytes, yet how
antigen recognition activates appropriate effector responses through nonspecific signaling …

T helper type 17 (Th17) cells are characterized by inherent plasticity and heterogeneity
displaying both pathogenic and tissue‐protective functions. Emerging evidence has …

T helper (Th) 17 cells encompass a spectrum of cell states, including cells that maintain
homeostatic tissue functions and pro-inflammatory cells that can drive autoimmune tissue …

The Pellino family is a novel and well-conserved E3 ubiquitin ligase family and consists of
Pellino1, Pellino2, and Pellino3. Each family member exhibits a highly conserved structure …