The protein translation machinery of the parasite Plasmodium is the target of important anti-
malarial drugs, and encompasses many promising targets for future drugs. Plasmodium …

Aminoacyl-tRNA synthetases (aaRSs) are modular enzymes globally conserved in the three
kingdoms of life. All catalyze the same two-step reaction, ie, the attachment of a …

Malaria infection triggers pro-inflammatory responses in humans that are detrimental to host
health. Parasite-induced enhancement in cytokine levels correlate with malaria-associated …

The Plasmodium falciparum protein translation enzymes aminoacyl-tRNA synthetases
(aaRSs) are an emergent family of drug targets. The aaRS ensemble catalyses transfer of …

Malaria, leishmaniasis, Chagas disease, and human African trypanosomiasis continue to
cause considerable suffering and death in developing countries. Current treatment options …

Aminoacyl-tRNA synthetases (aaRSs) are housekeeping enzymes that couple cognate
tRNAs with amino acids to transmit genomic information for protein translation. The …

Aminoacyl-tRNA synthetases (aaRSs) drive protein translation in cells and hence these are
essential enzymes across life. Inhibition of these enzymes can halt growth of an organism by …

Arthrobacter is one of the most prevalent genera of nicotine-degrading bacteria; however,
studies of nicotine degradation in Arthrobacter species remain at the plasmid level (plasmid …

The biological macromolecular world is homochiral and effective enforcement and
perpetuation of this homochirality is essential for cell survival. In this study, we present the …

D-aminoacyl-tRNA deacylase (DTD) removes D-amino acids mischarged on tRNAs and is
thus implicated in enforcing homochirality in proteins. Previously, we proposed that selective …