Cytokines exert powerful immunomodulatory effects that are critical to physiology and
pathology in humans. The application of natural cytokines in clinical studies has not been …

Nonalcoholic fatty liver disease (NAFLD) includes a spectrum of liver disorders, from fatty
liver to nonalcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma …

The NLRP3 inflammasome plays a crucial role in innate immune-mediated inflammation
and contributes to the pathogenesis of multiple autoinflammatory, metabolic and …

Liver fibrosis accompanies the progression of chronic liver diseases independent of
etiologies, such as hepatitis viral infection, alcohol consumption, and metabolic-associated …

Overexpression of pro-inflammatory cytokines and iNOS have been found to be concomitant
with several chronic inflammatory diseases and hence targeting their inhibition would be a …

Mucosal-associated invariant T cells or MAIT cells are an abundant cell type in humans and
especially so in the liver. MAIT cells are a subset of T lymphocytes that sit at a bridge …

The liver has unique regeneration potential, which ensures the continuous dependence of
the human body on hepatic functions. As the composition and function of gut microbiota has …

Kupffer cells (KCs), which are liver-resident macrophages, originate from the fetal yolk sac
and represent one of the largest macrophage populations in the body. However, the current …

Background A consensus of experts has proposed to replace the term nonalcoholic fatty
liver disease (NAFLD), whose global prevalence is 25%, with metabolic dysfunction …

Chronic liver diseases, eg, cholestasis, are negatively impacted by inflammation, which
further aggravates liver injury. Pharmacotherapy targeting the peroxisome proliferator …