Large bone defects are a major global health concern. Bone tissue engineering (BTE) is the
most promising alternative to avoid the drawbacks of autograft and allograft bone …

3D printed/bioprinted tissue constructs are utilized for the regeneration of damaged tissues
and as in vitro models. Most of the fabricated 3D constructs fail to undergo functional …

Tissue engineering (TE) is a strongly expanding research area. TE approaches require
biocompatible scaffolds, cells, and different applied stimuli, which altogether mimic the …

It has been observed that bone fractures carry a risk of high mortality and morbidity. The
deployment of a proper bone healing method is essential to achieve the desired success …

The repair of critical bone defects remains challenging worldwide. Three canonical pillars
(biomaterial scaffolds, bioactive molecules, and stem cells) of bone tissue engineering have …

Bioreactor systems are very precious tools to generate living bone grafts in vitro. The aim of
this study was to compare the effectiveness of rotating and perfusion bioreactor in the …

In the past decades, bone tissue engineering developed and exploited many typologies of
bioreactors, which, besides providing proper culture conditions, aimed at integrating those …

Stem cell-based therapy is a significant topic in regenerative medicine, with a predominant
role being played by human mesenchymal stem cells (hMSCs). The hMSCs have been …

Since the last decade, significant developments have been made in the area of bone tissue
engineering associated with the emergence of novel biomaterials as well as techniques of …

The osteochondral (OC) tissue is one of the most hierarchical and complex structures known
and it is composed by two main compartments of hyaline articular cartilage and subchondral …