As much as the cellular viability is important for the living organisms, the elimination of
unnecessary or damaged cells has the opposite necessity for the maintenance of …

Chemotherapy is the main strategy for the treatment of cancer. However, the main problem
limiting the success of chemotherapy is the development of multidrug resistance. The …

Ceramide is a group of sphingolipids found in cell membranes, composed of a sphingoid
base linked to a fatty acid of varying chain length. Initially regarded as purely structural …

The ceramide-sphingosine 1-phosphate (S1P) rheostat is important in regulating cell fate.
Several chemotherapeutic agents, including paclitaxel (Taxol), involve pro-apoptotic …

Drug resistance elicited by cancer cells still constitutes a huge problem that frequently
impairs the efficacy of both conventional and novel molecular therapies. Chemotherapy …

Escape of prostate cancer (PCa) cells from ionizing radiation–induced (IR-induced) killing
leads to disease progression and cancer relapse. The influence of sphingolipids, such as …

Beyond its role in recycling intracellular components nonselectively to sustain survival in
response to metabolic stresses, autophagy can also selectively degrade specific cargoes …

Urothelial carcinoma is the most common form of bladder cancer, but pathway changes that
occur with stage‐wise progression have not been well defined. We used a metabolomics …

Sphingolipid research has surged in the past two decades and has produced a wide variety
of evidence supporting the role of this class of molecules in mediating cellular growth …

Recurrent breast cancer is typically an incurable disease and, as such, is disproportionately
responsible for deaths from this disease. Recurrent breast cancers arise from the pool of …