The P2X7 receptor is a cation channel activated by high concentrations of adenosine
triphosphate (ATP). Upon long-term activation, it complexes with membrane proteins forming …

Purinergic neurotransmission, involving release of ATP as an efferent neurotransmitter was
first proposed in 1972. Later, ATP was recognised as a cotransmitter in peripheral nerves …

Calcium (Ca 2+) is an essential ligand that binds its primary intracellular receptor calmodulin
(CaM) to trigger a variety of downstream processes and pathways. Central to the actions of …

Ca2+/calmodulin-dependent protein kinase kinase (CaMKK) is the activating kinase for
multiple downstream kinases, including CaM-kinase I (CaMKI), CaM-kinase IV (CaMKIV) …

Psychiatric disorders are debilitating diseases, affecting> 80 million people worldwide.
There are no causal cures for psychiatric disorders and available therapies only treat the …

The purinergic receptor subtype 7 (P2X7R) represents a novel molecular target for imaging
neuroinflammation via PET. GSK1482160, a potent P2X7R antagonist, has high receptor …

The human P2X7 receptor is a trimeric ligand-gated cation channel coded by the P2XR7
gene located at chromosome position 12q24. P2X7 is expressed in a wide variety of normal …

Uric acid and purines (such as adenosine) regulate mood, sleep, activity, appetite, cognition,
memory, convulsive threshold, social interaction, drive, and impulsivity. A link between …

Genetic linkage studies have previously identified many single non-synonymous nucleotide
polymorphisms (SNPs) in the human P2RX7 gene in individuals with affective mood …

Psychiatric disorders describe different mental or behavioral patterns, causing suffering or
poor coping of ordinary life with manifold presentations. Multifactorial processes can …