Background: The cancer is still a major cause of death worldwide. Among different targets to
design anticancer agents, caspase-3 is an important target as its cleavage and activation …

Polyoxometalates (POMs), as emerging inorganic metal oxides, have been shown to have
significant biological activity and great medicinal value. Nowadays, biologically active POM …

The dual c-Met/vascular endothelial growth factor receptor 2 (VEGFR-2) TK inhibition is a
good strategy to overcome therapeutic resistance to small molecules VEGFR-2 inhibitors. In …

A new approach for the synthesis of podophyllotoxin-naphthoquinone compounds using
microwave-assisted three-component reactions is reported in this study. Novel …

An array of newly synthesized thieno [3, 2-d] pyrimidine-based derivatives and
thienotriazolopyrimidines hybridized with some pharmacophoric anticancer fragments were …

Nur77 is a potential target for the treatment of cancer such as HCC. Herein, we detailed the
discovery of a novel series of 5-((8-methoxy-2-methylquinolin-4-yl) amino)-1H-indole-2 …

In search for novel small molecules with antitumor cytotoxicity via activating procaspase-3,
we have designed and synthesized three series of novel (E)-N′-benzylidene-4 …

In continuation of our previous work on the investigation of CDK9 inhibitors bearing indole
moiety for the discovery of novel anticancer agents, novel methylenehydrazine-1 …

The present work was designed based on the new multi-component reaction, which forms 2-
aryl/alkyl-quinazolin-4 (3H)-ones in a one-pot reaction with good to excellent yields (86 …

In the effort to develop novel quinoline derivatives for the treatment of liver cancer, we
synthesized a series of N′-Substituted methylene-4-(quinoline-4-amino) …