Cell-laden hydrogels for osteochondral and cartilage tissue engineering
Despite tremendous advances in the field of regenerative medicine, it still remains
challenging to repair the osteochondral interface and full-thickness articular cartilage …
challenging to repair the osteochondral interface and full-thickness articular cartilage …
Current research on pharmacologic and regenerative therapies for osteoarthritis
Osteoarthritis (OA) is a degenerative joint disorder commonly encountered in clinical
practice, and is the leading cause of disability in elderly people. Due to the poor self-healing …
practice, and is the leading cause of disability in elderly people. Due to the poor self-healing …
Advanced silk fibroin biomaterials for cartilage regeneration
Silk fibroin is regarded as a natural fibrous protein with tunable mechanical properties,
acceptable biocompatibility, and favorable capability of enhancing attachment, proliferation …
acceptable biocompatibility, and favorable capability of enhancing attachment, proliferation …
The fabrication of biomimetic biphasic CAN-PAC hydrogel with a seamless interfacial layer applied in osteochondral defect repair
Cartilage tissue engineering based on biomimetic scaffolds has become a rapidly
developing strategy for repairing cartilage defects. In this study, a biphasic CAN-PAC …
developing strategy for repairing cartilage defects. In this study, a biphasic CAN-PAC …
Silk fibroin-chondroitin sulfate scaffold with immuno-inhibition property for articular cartilage repair
The demand of favorable scaffolds has increased for the emerging cartilage tissue
engineering. Chondroitin sulfate (CS) and silk fibroin have been investigated and reported …
engineering. Chondroitin sulfate (CS) and silk fibroin have been investigated and reported …
Emerging trend in the pharmacotherapy of osteoarthritis
W Zhang, WB Robertson, J Zhao, W Chen… - Frontiers in …, 2019 - frontiersin.org
Osteoarthritis (OA) is a degenerative joint disorder and one of the most prevalent diseases
among the elderly population. Due to the limited spontaneous healing capacity of articular …
among the elderly population. Due to the limited spontaneous healing capacity of articular …
[HTML][HTML] Bioactive scaffolds for osteochondral regeneration
C Deng, J Chang, C Wu - Journal of Orthopaedic Translation, 2019 - Elsevier
Abstract Treatment for osteochondral defects remains a great challenge. Although several
clinical strategies have been developed for management of osteochondral defects, the …
clinical strategies have been developed for management of osteochondral defects, the …
Mussel‐inspired tough hydrogel with in situ nanohydroxyapatite mineralization for osteochondral defect repair
Repairing osteochondral defects is a considerable challenge because it involves the
breakdown of articular cartilage and underlying bone. Traditional hydrogels with a …
breakdown of articular cartilage and underlying bone. Traditional hydrogels with a …
[HTML][HTML] Multifunctional polyphenol-based silk hydrogel alleviates oxidative stress and enhances endogenous regeneration of osteochondral defects
W Zhang, Y Zhang, X Li, Z Cao, Q Mo, R Sheng… - Materials Today Bio, 2022 - Elsevier
In osteochondral defects, oxidative stress caused by elevated levels of reactive oxygen
species (ROS) can disrupt the normal endogenous repair process. In this study, a …
species (ROS) can disrupt the normal endogenous repair process. In this study, a …
Bilayered silk/silk-nanoCaP scaffolds for osteochondral tissue engineering: in vitro and in vivo assessment of biological performance
Novel porous bilayered scaffolds, fully integrating a silk fibroin (SF) layer and a silk-nano
calcium phosphate (silk-nanoCaP) layer for osteochondral defect (OCD) regeneration, were …
calcium phosphate (silk-nanoCaP) layer for osteochondral defect (OCD) regeneration, were …