In animal cells, mitochondria are the primary powerhouses and metabolic factories. They
also contain genomes and can produce mitochondrial-specific nucleic acids and proteins …

Control of gene expression in erythropoiesis has to respond to signals that may emerge from
intracellular processes or environmental factors. Control of mRNA translation allows for …

Some mitochondrial long noncoding RNAs (lncRNAs) are encoded by nuclear DNA, but the
mechanisms that mediate their transport to mitochondria are poorly characterized. Using …

Various specialized domains have been described in the cytosol and the nucleus; however,
little is known about compartmentalization within the mitochondrial matrix. GRSF1 (G-rich …

Reactive oxygen species (ROS) produced in the ischemic myocardium can induce
cardiomyocyte injury and death, resulting in cardiac remodeling. Ferroptosis, known as a …

Emerging evidence has revealed that miRNAs could upregulate the expression levels of
target genes. However, the molecular mechanism underlying upregulation of targets …

Unrepaired DNA damage during embryonic development can be potentially inherited by a
large population of cells. However, the quality control mechanisms that minimize the …

Abstract miRNAs typically downregulate the expression of target genes by binding to their
3′ UTR and dysregulation of miRNAs may contribute to tumorigenesis. Here, we found that …

RNA-binding proteins (RBPs) are central players in post-transcriptional regulation and
immune homeostasis. The ribonuclease and RBP Regnase-1 exerts critical roles in both …

Spinal cord injury (SCI) can trigger multiple forms of neuronal cell death. Among these,
ferroptosis stands out as a particularly important style of cell death due to its iron overload …