[HTML][HTML] Piecing together the structural organisation of lipid exchange at membrane contact sites
R Khaddaj, W Kukulski - Current opinion in cell biology, 2023 - Elsevier
Membrane contact sites (MCSs) are areas of close proximity between organelles, implicated
in transport of small molecules and in organelle biogenesis. Lipid transfer proteins at MCSs …
in transport of small molecules and in organelle biogenesis. Lipid transfer proteins at MCSs …
Lipid Droplets Big and Small: Basic Mechanisms That Make Them All
RW Klemm, P Carvalho - Annual Review of Cell and …, 2024 - annualreviews.org
Lipid droplets (LDs) are dynamic storage organelles with central roles in lipid and energy
metabolism. They consist of a core of neutral lipids, such as triacylglycerol, which is …
metabolism. They consist of a core of neutral lipids, such as triacylglycerol, which is …
Zooming into lipid droplet biology through the lens of electron microscopy
W Dudka, VT Salo, J Mahamid - FEBS letters, 2024 - Wiley Online Library
Electron microscopy (EM), in its various flavors, has significantly contributed to our
understanding of lipid droplets (LD) as central organelles in cellular metabolism. For …
understanding of lipid droplets (LD) as central organelles in cellular metabolism. For …
[HTML][HTML] In situ studies of membrane biology by cryo-electron tomography
J Keller, R Fernández-Busnadiego - Current Opinion in Cell Biology, 2024 - Elsevier
Cryo-electron tomography (cryo-ET) allows high resolution 3D imaging of biological
samples in near-native environments. Thus, cryo-ET has become the method of choice to …
samples in near-native environments. Thus, cryo-ET has become the method of choice to …
CIDE proteins and their regulatory mechanisms in lipid droplet fusion and growth
The cell death‐inducing DFF45‐like effector (CIDE) proteins, including Cidea, Cideb, and
Cidec/Fsp27, regulate various aspects of lipid homeostasis, including lipid storage, lipolysis …
Cidec/Fsp27, regulate various aspects of lipid homeostasis, including lipid storage, lipolysis …
The role of lipid droplet associated proteins in inherited human disorders.
Proteins which associate with the surface of lipid droplets are intimately involved in the
regulation of the droplets. Several human inherited disorders have now been linked to loss …
regulation of the droplets. Several human inherited disorders have now been linked to loss …
Large transient assemblies of Apaf1 constitute the apoptosome in cells
AC Borgeaud, I Ganeva, C Klein, A Stooss… - bioRxiv, 2024 - biorxiv.org
Upon cell death signals, the apoptotic protease-activating factor Apaf1 and cytochrome c
interact to form the apoptosome complex. The apoptosome is crucial for mitochondrial …
interact to form the apoptosome complex. The apoptosome is crucial for mitochondrial …
The punctate localisation of the yeast sterol transporter Ysp2p is determined by three dimerisation interfaces in its C-terminus
GO Alli-Balogun, L Ivanović, W Kukulski, TP Levine - bioRxiv, 2023 - biorxiv.org
Sterol lipids traffic between intracellular compartments by vesicular and non-vesicular
routes. Sterol traffic from the plasma membrane to the endoplasmic reticulum (ER), so-called …
routes. Sterol traffic from the plasma membrane to the endoplasmic reticulum (ER), so-called …
PI (4) P recruits CIDE proteins to promote the formation of unilocular lipid droplets during adipogenesis and hepatic steatosis
J Wu, M Gao, X Wu, Y Liu, X Du, Y Liang, C Ma, P Li… - bioRxiv, 2024 - biorxiv.org
Lipid droplets (LDs) are evolutionarily conserved organelles that play important roles in
metabolism. Each LD is enclosed by a monolayer of phospholipids, distinct from bilayer …
metabolism. Each LD is enclosed by a monolayer of phospholipids, distinct from bilayer …