The recently discovered functions of RNA dramatically expand the cellular roles for this
macromolecule. RNA can no longer be viewed as a passive element, working simply as an …

In this paper, we review recent DNA-binding agents that are expected to influence the field
of DNA-targeting. We restrict ourselves to binders for which the three-dimensional structure …

In many repeat diseases, such as Huntington's disease (HD), ongoing repeat expansions in
affected tissues contribute to disease onset, progression and severity. Inducing contractions …

Microsatellite expansion, such as trinucleotide repeat expansion (TRE), is known to cause a
number of genetic diseases. Sanger sequencing and next-generation short-read …

Mismatched (non-Watson–Crick) base pairs represent the most common type of DNA
damage, as they are permanently formed in living cells due to erroneous insertion, deletion …

Nucleic acids are the molecular targets of many clinical anticancer drugs. However,
compared with proteins, nucleic acids have traditionally attracted much less attention as …

The luminescent characteristics of Ru (bpy) 2dppz2+ (dppz= dipyrido [3, 2-a: 2′, 3′-c]
phenazine), a DNA light switch, were investigated in the presence of oligonucleotides …

Synthetic small molecules modulating RNA structure and function have therapeutic potential
for RNA diseases. Here we report our discovery that naphthyridine carbamate dimer (NCD) …

DNA molecular glue is a small synthetic ligand that can adhere two single-stranded DNAs
that do not spontaneously hybridize with each other. For reversible control of DNA …

Abstract We identified 1113 articles (103 reviews, 1010 primary research articles) published
in 2005 that describe experiments performed using commercially available optical …