Targeting RNA with small molecules

JR Thomas, PJ Hergenrother - Chemical reviews, 2008 - ACS Publications
The recently discovered functions of RNA dramatically expand the cellular roles for this
macromolecule. RNA can no longer be viewed as a passive element, working simply as an …

DNA-binding drugs caught in action: the latest 3D pictures of drug-DNA complexes

DR Boer, A Canals, M Coll - Dalton Transactions, 2009 - pubs.rsc.org
In this paper, we review recent DNA-binding agents that are expected to influence the field
of DNA-targeting. We restrict ourselves to binders for which the three-dimensional structure …

A slipped-CAG DNA-binding small molecule induces trinucleotide-repeat contractions in vivo

M Nakamori, GB Panigrahi, S Lanni, T Gall-Duncan… - Nature …, 2020 - nature.com
In many repeat diseases, such as Huntington's disease (HD), ongoing repeat expansions in
affected tissues contribute to disease onset, progression and severity. Inducing contractions …

Interrogating the “unsequenceable” genomic trinucleotide repeat disorders by long-read sequencing

Q Liu, P Zhang, D Wang, W Gu, K Wang - Genome medicine, 2017 - Springer
Microsatellite expansion, such as trinucleotide repeat expansion (TRE), is known to cause a
number of genetic diseases. Sanger sequencing and next-generation short-read …

Finding needles in a basestack: recognition of mismatched base pairs in DNA by small molecules

A Granzhan, N Kotera… - Chemical Society Reviews, 2014 - pubs.rsc.org
Mismatched (non-Watson–Crick) base pairs represent the most common type of DNA
damage, as they are permanently formed in living cells due to erroneous insertion, deletion …

Structure‐based DNA‐targeting strategies with small molecule ligands for drug discovery

J Sheng, J Gan, Z Huang - Medicinal research reviews, 2013 - Wiley Online Library
Nucleic acids are the molecular targets of many clinical anticancer drugs. However,
compared with proteins, nucleic acids have traditionally attracted much less attention as …

Sensitivity of Ru(bpy)2dppz2+ Luminescence to DNA Defects

MH Lim, H Song, ED Olmon, EE Dervan… - Inorganic …, 2009 - ACS Publications
The luminescent characteristics of Ru (bpy) 2dppz2+ (dppz= dipyrido [3, 2-a: 2′, 3′-c]
phenazine), a DNA light switch, were investigated in the presence of oligonucleotides …

Small molecule targeting r(UGGAA)n disrupts RNA foci and alleviates disease phenotype in Drosophila model

T Shibata, K Nagano, M Ueyama, K Ninomiya… - Nature …, 2021 - nature.com
Synthetic small molecules modulating RNA structure and function have therapeutic potential
for RNA diseases. Here we report our discovery that naphthyridine carbamate dimer (NCD) …

Photoswitchable molecular glue for DNA

C Dohno, S Uno, K Nakatani - Journal of the American Chemical …, 2007 - ACS Publications
DNA molecular glue is a small synthetic ligand that can adhere two single-stranded DNAs
that do not spontaneously hybridize with each other. For reversible control of DNA …

Survey of the year 2005 commercial optical biosensor literature

RL Rich, DG Myszka - Journal of Molecular Recognition: An …, 2006 - Wiley Online Library
Abstract We identified 1113 articles (103 reviews, 1010 primary research articles) published
in 2005 that describe experiments performed using commercially available optical …