Mitochondrial glutathione: recent insights and role in disease

M Marí, E de Gregorio, C de Dios, V Roca-Agujetas… - Antioxidants, 2020 - mdpi.com
Mitochondria are the main source of reactive oxygen species (ROS), most of them deriving
from the mitochondrial respiratory chain. Among the numerous enzymatic and non …

Advanced glycation end products: sparking the development of diabetic vascular injury

A Goldin, JA Beckman, AM Schmidt, MA Creager - Circulation, 2006 - Am Heart Assoc
Advanced glycation end products (AGEs) are proteins or lipids that become glycated after
exposure to sugars. AGEs are prevalent in the diabetic vasculature and contribute to the …

Antioxidant and antidiabetic activity of algae

AM Abo-Shady, SF Gheda, GA Ismail, J Cotas… - Life, 2023 - mdpi.com
Currently, algae arouse a growing interest in the pharmaceutical and cosmetic area due to
the fact that they have a great diversity of bioactive compounds with the potential for …

Angiotensin-converting enzyme inhibitors or angiotensin receptor blockers for prevention of type 2 diabetes: a meta-analysis of randomized clinical trials

H Abuissa, PG Jones, SP Marso, JH O'Keefe - Journal of the American …, 2005 - jacc.org
Objectives: We sought to investigate the role of angiotensin-converting enzyme (ACE)
inhibitors and angiotensin receptor blockers (ARBs) in preventing the new onset of type 2 …

Mitochondrial function and toxicity: role of B vitamins on the one-carbon transfer pathways

F Depeint, WR Bruce, N Shangari, R Mehta… - Chemico-biological …, 2006 - Elsevier
The B vitamins are water-soluble vitamins that are required as coenzymes for reactions
essential for cellular function. This review focuses on the essential role of vitamins in …

Intervention strategies to inhibit protein carbonylation by lipoxidation‐derived reactive carbonyls

G Aldini, I Dalle‐Donne, RM Facino… - Medicinal research …, 2007 - Wiley Online Library
Protein carbonylation induced by reactive carbonyl species (RCS) generated by
peroxidation of polyunsaturated fatty acids plays a significant role in the etiology and/or …

Effects of pyridoxamine in combined phase 2 studies of patients with type 1 and type 2 diabetes and overt nephropathy

ME Williams, WK Bolton, RG Khalifah… - American journal of …, 2007 - karger.com
Background/Aims: Treatments of diabetic nephropathy (DN) delay the onset of end-stage
renal disease. We report the results of safety/tolerability studies in patients with overt …

The clinical relevance of assessing advanced glycation endproducts accumulation in diabetes

R Meerwaldt, T Links, C Zeebregts, R Tio… - Cardiovascular …, 2008 - Springer
Cardiovascular disease is the major cause of morbidity and mortality associated with
diabetes. There is increasing evidence that advanced glycation endproducts (AGEs) play a …

The Antidiabetic Activity of Nigella sativa and Propolis on Streptozotocin‐Induced Diabetes and Diabetic Nephropathy in Male Rats

HA El Rabey, MN Al-Seeni… - Evidence‐based …, 2017 - Wiley Online Library
This study was conducted to compare the ameliorative effect of Nigella sativa and propolis
methanol extract on streptozotocin‐induced diabetic male rats and treating diabetic …

Pro-inflammatory mechanisms in diabetic neuropathy: focus on the nuclear factor kappa B pathway

NE Cameron, MA Cotter - Current drug targets, 2008 - ingentaconnect.com
Neuropathy is a common complication of diabetes mellitus, which reduces the quality of life
and may be lifethreatening. The etiology is complex and multifactorial: hyperglycemia and …