Infection with high-risk human papillomavirus (HPV), including HPV-16 and HPV-18, is the
main cause of malignancies, such as cervical cancer. Viral oncoproteins encoded by HPV …

Background The role of cancer cell FOXP3 in tumorigenesis is conflicting. We aimed to study
FOXP3 expression and regulation, function and clinical implication in human non-small cell …

Cell signaling pathways are the mechanisms by which cells transduce external stimuli,
which control the transcription of genes, to regulate diverse biological effects. In cancer …

Purpose: Our purpose was to characterize the clinical influences, genetic risk factors, and
gene mechanisms contributing to persistent cisplatin-induced peripheral neuropathy …

Abstract RNA polymerase II (RNAPII) is responsible for the synthesis of a diverse set of RNA
molecules, including protein-coding messenger RNAs (mRNAs) and many short non-coding …

Cancers remain a threat to human health due to the lack of effective therapeutic strategies.
Great effort has been devoted to the discovery of drug targets to treat cancers, but novel …

Proteolysis targeting chimera (PROTAC) presents a powerful strategy for targeted protein
degradation (TPD). The heterobifunctional PROTAC molecule consists of an E3 ligase …

Accumulating evidence has suggested that microRNA-449b-5p (miR-449b-5p) plays an
important role in the development and progression of multiple cancers. However, little is …

Lung cancer, especially lung adenocarcinoma, is one of the most common neoplasms
worldwide. However, the mechanisms underlying its initiation, development, and metastasis …

Gastric cancer, like most of other cancers, has an uncontrolled cell cycle regulated by cyclins
and cyclin-dependent kinases (CDKs). In this study, we reported that gastric cancer cells …