Sensitivity analysis is an important part of a mathematical modeller's toolbox for model
analysis. In this review paper, we describe the most frequently used sensitivity techniques …

Tissue kallikreins are a family of fifteen secreted serine proteases encoded by the largest
protease gene cluster in the human genome. In the past decade, substantial progress has …

During the last decades, high-throughput assessment of gene expression in patient tissues
using microarray technology or RNA-Seq took center stage in clinical research. Insights into …

An intact barrier function of the skin is important in maintaining skin health. The regulation of
the skin barrier depends on a multitude of molecular and immunological signaling pathways …

Inflammation plays a major role in the induction and progression of several skin diseases.
Overexpression of the major epidermal proinflammatory cytokines interleukin (IL) 1 alpha (IL …

Background The skin barrier acts as the first line of defense against constant exposure to
biological, microbial, physical, and chemical environmental stressors. Dynamic interplay …

Kallikrein-related peptidases (KLKs) are a family of secreted serine proteases, which form a
network (the KLK activome) with an important role in proteolysis and signaling. In prostate …

Background The skin is largely comprised of keratinocytes within the interfollicular
epidermis. Over approximately two weeks these cells differentiate and traverse the thickness …

The skin acts as a mechanical barrier that protects the body from the exterior environment,
and skin barrier function is attributed to the stratum corneum (SC), which is composed of …

Keratinocytes are epithelial cells that make up the stratified epidermis of the skin. Recent
studies suggest that keratinocytes promote chronic itch. Changes in skin morphology that …