This publication introduces a series of eight other publications describing the non-clinical
assessment and initial clinical study of a candidate modified risk tobacco product (MRTP) …

The health risks of tobacco smoking have been documented in numerous studies and
smoking rates have declined in developed countries over the last 50 years. Today, we know …

Tobacco-free 'modern'oral nicotine pouches (MOPs), are similar in appearance and use to
Swedish-style snus, but without tobacco. There are few identified methods to create test …

Various electronic nicotine delivery systems (ENDS), of which electronic cigarettes (e-cigs)
are the most recognized prototype, have been quickly gaining ground on conventional …

Cigarette smoke increases the risk for respiratory and other diseases. Although smoking
prevalence has declined over the years, millions of adults choose to continue to smoke …

Cigarette smoking is a major risk factor for many adverse health conditions. Novel tobacco
heating products (THPs) heat tobacco, reducing exposure to many of the harmful …

We previously proposed a systems toxicology framework for in vitro assessment of e-liquids.
The framework starts with the first layer aimed at screening the potential toxicity of e-liquids …

In vitro (geno) toxicity assessment of electronic vapour products (EVPs), relative to
conventional cigarette, currently uses assays, including the micronucleus and Ames tests …

Purpose Numerous studies have reported that glioma patients with isocitrate
dehydrogenase 1 (IDH1) R132H mutation are sensitive to temozolomide treatment …

Aging and smoking are major risk factors for cardiovascular diseases (CVD). Our in vitro
study compared, in the context of aging, the effects of the aerosol of Tobacco Heating …