Effect of intra-articular platelet-rich plasma vs placebo injection on pain and medial tibial cartilage volume in patients with knee osteoarthritis: the RESTORE …

KL Bennell, KL Paterson, BR Metcalf, V Duong, J Eyles… - Jama, 2021 - jamanetwork.com
Importance Most clinical guidelines do not recommend platelet-rich plasma (PRP) for knee
osteoarthritis (OA) because of lack of high-quality evidence on efficacy for symptoms and …

[HTML][HTML] Characterization and therapeutic use of extracellular vesicles derived from platelets

T Spakova, J Janockova, J Rosocha - International Journal of Molecular …, 2021 - mdpi.com
Autologous blood products, such as platelet-rich plasma (PRP), are gaining increasing
interest in different fields of regenerative medicine. Although growth factors, the main …

[HTML][HTML] Intra-articular injections of platelet-rich plasma in symptomatic knee osteoarthritis: a consensus statement from French-speaking experts

F Eymard, P Ornetti, J Maillet, É Noel, P Adam… - Knee Surgery, Sports …, 2021 - Springer
Purpose There has been much debate regarding the use of intra-articular injections of
platelet-rich plasma (PRP) as symptomatic treatment for knee osteoarthritis. The objective of …

[HTML][HTML] Action of platelet-rich plasma on in vitro cellular bioactivity: more than platelets

M Beitia, D Delgado, J Mercader, P Sánchez… - International Journal of …, 2023 - mdpi.com
Platelet-rich plasma (PRP) is a biological therapy in which one of the mechanisms of action
is the stimulation of biological processes such as cell proliferation. The size of PRP's effect …

Latest insights in disease-modifying osteoarthritis drugs development

S Li, P Cao, T Chen, C Ding - Therapeutic Advances in …, 2023 - journals.sagepub.com
Osteoarthritis (OA) is a prevalent and severely debilitating disease with an unmet medical
need. In order to alleviate OA symptoms or prevent structural progression of OA, new drugs …

Platelet-rich plasma combined with hyaluronic acid improves pain and function compared with hyaluronic acid alone in knee osteoarthritis: a systematic review and …

T Karasavvidis, T Totlis, R Gilat, BJ Cole - Arthroscopy: The Journal of …, 2021 - Elsevier
Purpose To evaluate the efficacy of platelet-rich plasma (PRP) combined with hyaluronic
acid (HA) injections versus HA injections alone for the management of knee osteoarthritis …

Low-temperature three-dimensional printing of tissue cartilage engineered with gelatin methacrylamide

C Luo, R Xie, J Zhang, Y Liu, Z Li, Y Zhang… - … Engineering Part C …, 2020 - liebertpub.com
Low-concentration gelatin methacryloyl (GelMA) hydrogels have been found to be promising
cell-laden bioinks with excellent cell viability. Herein, we report a strategy that accurately …

The 2020 NBA orthobiologics consensus statement

BJ Cole, R Gilat, J DiFiori… - Orthopaedic journal of …, 2021 - journals.sagepub.com
This 2020 NBA Orthobiologics Consensus Statement provides a concise summary of
available literature and practical clinical guidelines for team physicians and players. We …

[HTML][HTML] Characterization and chondroprotective effects of extracellular vesicles from plasma-and serum-based autologous blood-derived products for osteoarthritis …

A Otahal, K Kramer, O Kuten-Pella, R Weiss… - … in bioengineering and …, 2020 - frontiersin.org
Autologous blood products gain increasing interest in the field of regenerative medicine as
well as in orthopedics, aesthetic surgery, and cosmetics. Currently, citrate-anticoagulated …

Improved biological performance of human cartilage-derived progenitors in platelet lysate xenofree media in comparison to fetal bovine serum media

VP Mantripragada, GF Muschler - Current Research in Translational …, 2022 - Elsevier
Primary articular cartilage-derived cells are among the preferred contenders for cell-based
therapy approaches for cartilage repair. Limited access to primary human cartilage tissue …