Organs-on-chips are microengineered microfluidic living cell culture devices with
continuously perfused chambers penetrating to cells. By mimicking the biological features of …

The blood–brain barrier (BBB) represents a key challenge in developing brain-penetrating
therapeutic molecules. BBB dysfunction is also associated with the onset and progression of …

The inefficiency of existing animal models to precisely predict human pharmacological
effects is the root reason for drug development failure. Microphysiological system/organ-on …

The integration of biochips with AI opened up new possibilities and is expected to
revolutionize smart healthcare tools within the next five years. The combination of …

The traditional two-dimensional (2D) cell culture methods have a long history of mimicking in
vivo cell growth. However, these methods cannot fully represent physiological conditions …

The core of the drug research and screening processes is predicting the effect of drugs prior
to human clinical trials. Due to the 2D cell culture and animal models' poor predictability, the …

There is an urgent need for predictive in vitro models to improve disease modeling and drug
target identification and validation, especially for neurological disorders. Cerebral …

Abstract 3D printing technology has opened a new paradigm to controllably and
reproducibly fabricate bioengineered neural constructs for potential applications in repairing …

The human brain is a complex organ composed of many different types of cells
interconnected to create an organized system able to efficiently process information …

Neuronal cultures are a prominent experimental tool to understand complex functional
organization in neuronal assemblies. However, neurons grown on flat surfaces exhibit a …