Herpes simplex virus (HSV) type 1 and 2 are old viruses, with a history of evolution shared
with humans. Thus, it is generally well-adapted viruses, infecting many of us without doing …

Herpesvirus infection leads to the rapid induction of an innate immune response. A central
aspect of this host response is the production and secretion of type I interferon. The current …

Natural interferon-producing cells (IPCs) specialize in the production of high levels of type 1
interferons (IFNs) in response to encapsulated DNA and RNA viruses. Here we demonstrate …

Mechanisms responsible for neuroattenuation of herpes simplex virus (HSV) have been
defined previously by studies of mutant viruses in cultured cells. The hypothesis that null …

The presence and potential functions of resident plasmacytoid dendritic cells (pDCs) in
peripheral tissues is unclear. We report that pDCs constitutively populate naïve corneas and …

The ability of alpha interferon (IFN-α) and IFN-γ to inhibit transmission of herpes simplex
virus type 1 (HSV-1) from neuronal axon to epidermal cells (ECs), and subsequent spread in …

The interferon (IFN) family of cytokines constitutes potent inducers of innate antiviral
responses that also influence adaptive immune processes. Despite eliciting such formidable …

The precise role of each of the seven individual CD11c+ dendritic cell subsets (DCs)
identified to date in the response to viral infections is not known. DCs serve as critical links …

This review is dedicated to the influence of type I IFNs (also called IFN-α/β) in the central
nervous system (CNS). Studies in mice with type I IFN receptor or IFN-β gene deficiency …

Background A subset of patients with atopic dermatitis (AD) is prone to disseminated herpes
simplex virus (HSV) infection (ie, atopic dermatitis with a history of eczema herpeticum …