A defining property of cytotoxic lymphocytes is their expression and regulated secretion of
potent toxins, including the pore-forming protein perforin and serine protease granzymes …

Macrophage activation syndrome (MAS), or secondary hemophagocytic lymphohistiocytosis
(HLH), is a cytokine storm syndrome associated with multi-organ system dysfunction and …

Immunotherapy has revolutionized outcomes for cancer patients, but the mechanisms of
resistance remain poorly defined. We used a series of whole-genome clustered regularly …

Abstract Background. Severe H1N1 influenza can be lethal in otherwise healthy individuals
and can have features of reactive hemophagocytic lymphohistiocytosis (HLH). HLH is …

Multiple sclerosis is a complex neurological disease, with∼ 20% of risk heritability
attributable to common genetic variants, including> 230 identified by genome-wide …

The function of MR1-restricted mucosal-associated invariant T (MAIT) cells in tumor
immunity is unclear. Here we show that MAIT cell-deficient mice have enhanced NK cell …

Since the first textbook devoted to cytokine storm syndromes (CSSs) was published in 2019,
the world has changed dramatically and the term's visibility has broadened. Herein, we …

Granzymes are a family of small (∼ 32 kDa) serine proteases with a range of substrate
specificities that are stored in, and released from, the cytoplasmic secretory vesicles …

Chimeric antigen receptor (CAR) T-cell therapy has proven successful in the treatment of
hematological malignancies, notably acute lymphoblastic leukemia and B-cell lymphoma …

Cytokine storm syndromes (CSSs) are potentially fatal hyperinflammatory states that share
the underpinnings of persistent immune cell activation and uninhibited cytokine production …