Oxidative stress plays a key role in many physiological and pathological conditions. The
intracellular oxidative homeostasis is tightly regulated by the reactive oxygen species …

Optimal healing of damaged tissue following myocardial infarction (MI) requires a
coordinated cellular response that can be divided into three phases: inflammatory …

In the healthy heart, cardiac myocytes form an electrical syncytium embedded in a
supportive fibroblast-rich extracellular matrix designed to optimize the electromechanical …

Cardiac arrhythmias can cause sudden cardiac death (SCD) and add to the current heart
failure (HF) health crisis. Nevertheless, the pathological processes underlying arrhythmias …

Diseases of the heart and the kidney, including heart failure and chronic kidney disease, can
dramatically impair life expectancy and the quality of life of patients. The heart and kidney …

The multifunctional Ca2+-and calmodulin-dependent protein kinase II (CaMKII) is now
recognized to play a central role in pathological events in the cardiovascular system. CaMKII …

Myocardial fibrosis is an important risk factor for cardiac arrhythmias. Previous experimental
and numerical studies have shown that the texture and spatial distribution of fibrosis may …

Current therapies for arrhythmia using ion channel blockade, catheter ablation, or an
implantable cardioverter defibrillator have limitations, and it is important to search for new …

Aging of the heart is associated with a blunted response to sympathetic stimulation, reduced
contractility, and increased propensity for arrhythmias, with the risk of sudden cardiac death …

CaMKII is activated by oxidation of methionine residues residing in the regulatory domain.
Oxidized CaMKII (ox-CaMKII) is now thought to participate in cardiovascular and pulmonary …