The structural and functional diversity of lipids accounts for their involvement into a wide
range of homeostatic processes and disease states, including lifestyle‐related diseases as …

Multiphoton laser scanning microscopy has proven profound value for ex vivo 3D histology
and in vivo imaging of motionless tissue. The development of triggering systems and fast …

Objectives This study aimed to systematically investigate whether plaque autofluorescence
properties assessed with intravascular fluorescence lifetime imaging (FLIm) can provide …

Comprehensive imaging of both the structural and biochemical characteristics of
atherosclerotic plaque is essential for the diagnosis and study of coronary artery disease …

Blind linear unmixing (BLU) methods decompose multi and hyperspectral datasets into end-
members and abundance maps with an unsupervised perspective. However, due to …

Fluorescence spectroscopy and lifetime techniques are potential methods for optical
diagnosis and characterization of biological tissues with an in-situ, fast, and noninvasive …

The pathophysiological progression of chronic diseases, including atherosclerosis and
cancer, is closely related to compositional changes in biological tissues containing …

Coronary plaque destabilization involves alterations in microstructure and biochemical
composition; however, no imaging approach allows such comprehensive characterization …

A fluorescence lifetime imaging microscopy (FLIM) integrated with two-photon excitation
technique was developed. A wavelength-tunable femtosecond pulsed laser with nominal …

Frequency domain (FD) fluorescence lifetime imaging (FLIM) involves the excitation of the
sample of interest with a modulated light source and digitization of the fluorescence …