Glomerular podocytes are highly specialized cells with a complex cytoarchitecture. Their
most prominent features are interdigitated foot processes with filtration slits in between …

As an integral member of the filtration barrier in the kidney glomerulus, the podocyte is in a
unique geographical position: It is exposed to chemical signals from the urinary space …

Mature podocytes are among the most complex differentiated cells and possess a highly
branched array of foot processes that are essential to glomerular filtration in the kidney …

The mechanisms leading to the recovery of the kidney after ischemic acute renal failure are
poorly understood. To explore the role played by mitogenesis and dedifferentiation in this …

Abstract The Wilms' Tumour gene WT1 has important functions during development. Knock-
out mice were shown to have defects in the urogenital system and to die at embryonic day …

Human genetic and in vivo studies have helped to define the critical importance of
podocytes for kidney function in health and disease. However, as in any other research …

Ischemic injury to the kidney produces acute tubular necrosis and apoptosis followed by
tubular regeneration and recovery of renal function. Although mitotic cells are present in the …

Glomerular visceral epithelial cells, also termed podocytes, are highly specialized epithelial
cells that cover the outer aspect of the glomerular basement membrane. Recent studies …

In the course of immunohistochemical studies it has become apparent that there is a distinct
phenotype of keratin expression that is shared by basal epithelial cells in a variety of …

Renal myofibroblasts may be derived from tubular epithelial cells by a process of tubular
epithelial-myofibroblast transdifferentiation. Transforming growth factor-β signals through …