Neoplastic cells need to adapt their gene expression pattern to survive in an ever-changing
or unfavorable tumor microenvironment. Protein synthesis (or mRNA translation), an …

Abstract LIN28B is an RNA-binding protein that targets a broad range of microRNAs and
modulates their maturation and activity. Under normal conditions, LIN28B is exclusively …

Metabolic pathways dynamically regulate tissue development and maintenance. However,
the mechanisms that govern the metabolic adaptation of stem or progenitor cells to their …

Fetal hematopoietic stem and progenitor cells (HSPCs) hold promise to cure a wide array of
hematological diseases, and we previously found a role for the RNA-binding protein (RBP) …

Intestinal epithelial transit-amplifying cells are essential stem progenitors required for
intestinal homeostasis, but their rapid proliferation renders them vulnerable to DNA damage …

Organisms can adapt to an environment by taking multiple mutational paths. This
redundancy at the genetic level, where many mutations have similar phenotypic and fitness …

Ewing sarcoma (EwS) is associated with poor prognosis despite current multimodal therapy.
Targeting of EWS-FLI1, the fusion protein responsible for its pathogenesis, and its principal …

RNA binding proteins, including IMP 1/IGF 2 BP 1, are essential regulators of intestinal
development and cancer. Imp1 hypomorphic mice exhibit gastrointestinal growth defects, yet …

Most colorectal cancers (CRCs) are moderately differentiated or well differentiated, a status
that is preserved even in metastatic tumors. However, the molecular mechanisms underlying …

Stem cells are essential for the development and long-term maintenance of tissues and
organisms. Preserving tissue homeostasis requires exquisite control of all aspects of stem …