Single-molecule magnetic tweezers deliver magnetic force and torque to single target
molecules, permitting the study of dynamic changes in biomolecular structures and their …

In addition to biochemical signals and genetic considerations, mechanical forces are rapidly
emerging as a master regulator of human physiology. However, the molecular mechanisms …

Protein folding occurs as a set of transitions between structural states within an energy
landscape. An oversimplified view of the folding process emerges when transiently …

Single-molecule force spectroscopy sheds light onto the free energy landscapes governing
protein folding and molecular recognition. Since only a single molecule or single molecular …

Coupling of mechanical forces and chemical transformations is central to the biophysics of
molecular machines, polymer chemistry, fracture mechanics, tribology, and other disciplines …

Rapid and sensitive detection technologies for food contaminants play vital roles in food
safety. Due to the complexity of the food matrix and the trace amount distribution, traditional …

Exploring the relationship between the polymer structure and property/function is a long-
lasting topic in polymer science since relevant research is critical for the rational design of …

A wealth of chemical bonds and polymers have been studied with single-molecule force
spectroscopy, usually by applying a force perpendicular to the anchoring surface. However …

Conformational memory in single-molecule dynamics has attracted recent attention and, in
particular, has been invoked as a possible explanation of some of the intriguing properties of …

Atomic force microscopy (AFM)-based single-molecule force spectroscopy (SMFS) is a
powerful yet accessible means to characterize mechanical properties of biomolecules …