The screening and testing of extracts against a variety of pharmacological targets in order to
benefit from the immense natural chemical diversity is a concern in many laboratories …

Cancer is one of the diseases with high morbidity and mortality on a global scale.
Chemotherapy remains the primary treatment option for most cancer patients, including …

Introduction Spirocyclic scaffolds are an exceptional tool in drug design, allowing fine-tuning
of a molecule's conformational and physicochemical properties. As it expands and …

The diterpenoids present highly varied oxidation patterns subjected to fascinating skeletal
rearrangements, and possess antitumor, antibacterial, antihyperglycemic, anti-inflammatory …

Triple-negative breast cancer (TNBC) is one of the most highly invasive and metastatic
breast cancers without safe and effective therapeutic drugs. The natural product oridonin is …

The biological function of the natural ent-kaurene diterpenoid isolated from genus Isodon,
oridonin, has been intensively studied. However, its mechanism studies and clinical …

Many of the clinically used anticancer agents in Western medicine are derived from
secondary metabolites found in terrestrial microbes, marine organisms, and higher plants …

Targeting NLRP3 inflammasome with inhibitors is a novel strategy for NLRP3-driven
diseases. Herein, hit compound 5 possessing an attractive skeleton was identified from our …

Covering January to December 2017; previous review Nat. Prod. Rep., 2017, 34, 1233–
1243. This review covers the isolation and chemistry of diterpenoids from terrestrial as …

Cancer incidences are rising each year. In 2020, approximately 20 million new cancer cases
and 10 million cancer‐related deaths were recorded. The World Health Organization (WHO) …