Acute kidney injury (AKI) is the leading cause of nephrology consultation and is associated
with high mortality rates. The primary causes of AKI include ischemia, hypoxia or …

Inflammation, a process intimately linked to renal disease, can be defined as a complex
network of interactions between renal parenchymal cells and resident immune cells, such as …

Chronic and acute renal diseases, irrespective of the initiating cause, have inflammation and
immune system activation as a common underlying mechanism. The purpose of this review …

Puromycin aminonucleoside nephrosis (PAN), a rat model of human minimal change
nephropathy, is characterized by extensive flattening of glomerular epithelial cell (podocyte) …

The role of the vascular endothelium in progressive renal disease is not well understood.
This review presents evidence that progressive renal disease is characterized by a …

Molecular mechanisms of diabetic renal hypertrophy. Altered growth of renal cells is one of
the early abnormalities detected after the onset of diabetes. Cell culture studies whereby …

Leptin stimulates proliferation and TGF-β expression in renal glomerular endothelial cells:
Potential role in glomerulosclerosis. Background Leptin inhibits food intake and increases …

Platelet-derived growth factor-B (PDGFB) is necessary for normal cardiovascular
development, but the relative importance of different cellular sources of PDGFB has not …

The PDGF system, comprising four isoforms (PDGF-A,-B,-C, and-D) and two receptor chains
(PDGFR-α and-β), plays important roles in wound healing, atherosclerosis, fibrosis, and …

Kidney glomerulus mesangial cells fail to develop in mice carrying targeted null mutations in
the platelet-derived growth factor (PDGF)-B or PDGF-Rβ genes. We have examined the …