Since the discovery of the first trypsinogen mutation in families with hereditary pancreatitis,
pancreatic genetics has made rapid progress. The identification of mutations in genes …

Pancreatitis is a common disorder with significant morbidity and mortality, yet little is known
about its pathogenesis, and there is no specific or effective treatment. Its development …

Premature activation of digestive enzymes in the pancreas has been linked to development
of pancreatitis for more than a century. Recent development of novel models to study the …

Acute pancreatitis is an inflammatory disorder of the exocrine pancreas associated with
tissue injury and necrosis. The disease can be mild, involving only the pancreas, and …

Acute pancreatitis is an acute inflammatory process of the pancreas that frequently involves
peripancreatic tissues and at times remote organ systems. The severity of the disease varies …

Autodigestion of the pancreas by its own prematurely activated digestive proteases is
thought to be an important event in the onset of acute pancreatitis. The mechanism …

Over the past twenty years, thousands of physicians have come to depend on Yamada's
Textbook of Gastroenterology. Its encyclopaedic discussion of the basic science underlying …

The pathogenic mechanisms underlying acute pancreatitis are not clear. Two key pathologic
acinar cell responses of this disease are vacuole accumulation and trypsinogen activation …

Recent advances challenge the long-believed trypsin-centered understanding of
pancreatitis. It is becoming increasingly clear that activation of intense inflammatory …

BACKGROUND & AIMS:: Intrapancreatic activation of digestive enzymes is a key event in
the parenchymal cell injury of pancreatitis. We hypothesized that neutrophils recruited to the …