Chemical warfare agents constitute one of the greatest threats in the modern world. Among
them, the neurotoxic agents are of special interest due to their high lethality and danger …

The use of organophosphorus pesticides results in toxicity risk to non-target organisms.
Organophosphorus compounds share a common mode of action, exerting their toxic effects …

Acetylcholinesterase reactivators are crucial antidotes for the treatment of organophosphate
intoxication. Among the organophosphates, with the exception of soman, tabun (GA) …

The nerve agents are chemical warfare agents known to be used during terrorist attacks. An
inexpensive and portable system to be used by first responders and military personnel is of …

Abstract The oximes pralidoxime (2-PAM), its dimethanesulphonate salt derivative P2S, and
obidoxime (toxogonin) are currently licensed and fielded for the treatment of chemical …

The traditional therapeutic treatment of organophosphate cholinesterase inhibitor (nerve
agents) poisoning consists of co-treatment with an antimuscarinic (atropine) and a …

In the search for new oximes with higher reactivation potency and a broader spectrum, K‐27
and K‐48, have recently been synthesized. To test if their superior efficacy was related to …

The enzyme organophosphorus acid anhydrolase (OPAA), from Alteromonas sp. JD6. 5, has
been shown to rapidly catalyze the hydrolysis of a number of toxic organophosphorus …

V-agents are exceedingly toxic organophosphate nerve agents. The most widely known V-
agents are the phosphonylated thiocholines VX and VR. Nonetheless, other V-subclasses …

The deleterious effects of nerve agents over the enzymes acetylcholinesterase (AChE) and
butyrylcholinesterase (BChE) turned these compounds into the most dangerous chemical …