Preventing and controlling influenza virus infection remains a global public health
challenge, as it causes seasonal epidemics to unexpected pandemics. These infections are …

Influenza A virus (IAV) is the sole cause of the unpredictable influenza pandemics and
deadly zoonotic outbreaks and constitutes at least half of the cause of regular annual …

The integral membrane protein M2 of influenza virus forms pH-gated proton channels in the
viral lipid envelope. The low pH of an endosome activates the M2 channel before …

Adamantanes (amantadine and rimantadine) have been used to prevent and treat influenza
A virus infections for many years; however, resistance to these drugs has been widely …

Influenza causes annual epidemics of respiratory viral infections are associated with
significant morbidity and mortality. Influenza vaccines have been shown to reduce the risk of …

We examined the distribution of genetic mutations associated with resistance to the M2 ion
channel–blocking adamantane derivatives, amantadine and rimantadine, among H5N1 …

The coronavirus responsible for the severe acute respiratory syndrome (SARS‐CoV)
contains a small envelope protein, E, with putative involvement in host cell apoptosis and …

During the last decade there has been significant progress in the development of analytical
techniques for the screening of ligand binding to membranes and membrane receptors. This …

Influenza A and B viruses contain proton-selective ion channels, A/M2 and BM2,
respectively, and the A/M2 channel activity is inhibited by the drugs amantadine and its …

Amantadine is known to block the M2 proton channel of the Influenza A virus. Here, we
present a structure of the M2 trans-membrane domain blocked with amantadine, built using …