Review of biomarkers in ocular matrices: challenges and opportunities

M Tamhane, S Cabrera-Ghayouri, G Abelian… - Pharmaceutical …, 2019 - Springer
Biomarkers provide a powerful and dynamic approach to improve our understanding of the
mechanisms underlying ocular diseases with applications in diagnosis, disease modulation …

Roles of exosomes in the normal and diseased eye

M Klingeborn, WM Dismuke, CB Rickman… - Progress in retinal and …, 2017 - Elsevier
Exosomes are nanometer-sized vesicles that are released by cells in a controlled fashion
and mediate a plethora of extra-and intercellular activities. Some key functions of exosomes …

ProteomicsDB: toward a FAIR open-source resource for life-science research

L Lautenbacher, P Samaras, J Muller… - Nucleic Acids …, 2022 - academic.oup.com
Abstract ProteomicsDB (https://www. ProteomicsDB. org) is a multi-omics and multi-
organism resource for life science research. In this update, we present our efforts to …

Investigation of the global protein content from healthy human tears

M Dor, S Eperon, PH Lalive, Y Guex-Crosier… - Experimental eye …, 2019 - Elsevier
Considering absence of invasiveness and side effects, tears emerge as a particularly
attractive fluid for biomarker discovery and therefore for daily clinical use. However, to date …

The human eye proteome project: updates on an emerging proteome

MT Ahmad, P Zhang, C Dufresne, L Ferrucci… - …, 2018 - Wiley Online Library
The human eye is a complex organ consisting of multiple compartments with unique and
specialized properties that reflect their varied functions. Although there have been …

Importance of the use of oxidative stress biomarkers and inflammatory profile in aqueous and vitreous humor in diabetic retinopathy

AK López-Contreras, MG Martínez-Ruiz… - Antioxidants, 2020 - mdpi.com
Diabetic retinopathy is one of the leading causes of visual impairment and morbidity
worldwide, being the number one cause of blindness in people between 27 and 75 years …

[HTML][HTML] Advancements in Hydrogels for Corneal Healing and Tissue Engineering

KY Wu, SY Qian, A Faucher, SD Tran - Gels, 2024 - mdpi.com
Hydrogels have garnered significant attention for their versatile applications across various
fields, including biomedical engineering. This review delves into the fundamentals of …

Human aqueous humor proteome in cataract, glaucoma, and pseudoexfoliation syndrome

AA Kliuchnikova, NI Samokhina, IY Ilina… - …, 2016 - Wiley Online Library
Twenty‐nine human aqueous humor samples from patients with eye diseases such as
cataract and glaucoma with and without pseudoexfoliation syndrome were characterized by …

Elevated dimethylarginine, ATP, cytokines, metabolic remodeling involving tryptophan metabolism and potential microglial inflammation characterize primary open …

SK Pulukool, SKS Bhagavatham, V Kannan… - Scientific Reports, 2021 - nature.com
Glaucoma of which primary open angle glaucoma (POAG) constitutes 75%, is the second
leading cause of blindness. Elevated intra ocular pressure and Nitric oxide synthase (NOS) …

[HTML][HTML] Suppl-1, M9: Pathophysiology of Keratoconus: What Do We Know Today

U Soiberman, JW Foster, AS Jun… - The open …, 2017 - ncbi.nlm.nih.gov
Keratoconus is a common corneal ectasia that leads to progressive visual impairment.
Numerous studies have shown abnormal protein expression patterns in keratoconic …