Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used for the treatment of
skeletal injuries. The ability of NSAIDs to reduce pain and inflammation is well-established …

A potential cause of suffering in animal experimentation is pain induced by procedures,
diseases, and injuries. Pain is not only nociception, the sensory nervous system's response …

Whether sensory nerve can sense bone density or metabolic activity to control bone
homeostasis is unknown. Here we found prostaglandin E2 (PGE2) secreted by osteoblastic …

These animal data, together with the view of limited scientifically robust clinical evidence in
humans, indicate that physicians consider only short-term administration of COX-2 inhibitors …

The high worldwide prevalence of osteoporosis means it is considered a serious public
health concern, possibly leading to physical disability and an increased mortality rate …

Nonspecific and COX-2 selective nonsteroidal anti-inflammatory drugs (NSAIDs) function by
inhibiting the cyclooxygenase isoenzymes and effectively reduce pain and inflammation …

Low-level laser therapy (LLLT) has been found to produce anti-inflammatory effects in a
variety of disorders. Tendinopathies are directly related to unbalance in expression of pro …

Breast cancer has a high incidence worldwide. The results of substantial studis reveal that
inflammation plays an important role in the initiation, development, and aggressiveness of …

Skeletal interoception regulates bone homeostasis through the prostaglandin E2 (PGE2)
concentration in bone. Vertebral endplates undergo ossification and become highly porous …

The failure of remodeling process that constantly regenerates effete, aged bone is highly
associated with bone nonunion and degenerative bone diseases. Numerous studies have …