Alzheimer's disease (AD) is a fatal neurodegenerative disease in which senile plaques and
neurofibrillary tangles are crucially involved in its physiological and pathophysiological …

Methylene blue (MB) is a well-established drug with a long history of use, owing to its
diverse range of use and its minimal side effect profile. MB has been used classically for the …

Once perceived as solitary structures, mitochondria are now recognized as highly dynamic,
interconnected organelles. The tight control of their fusion and fission, a process termed …

Abstract A number of N-(2-(1H-indol-3-yl) ethyl)-2-oxo-2H-chromene-3-carboxamides were
synthesized and tested against AChE and BuChE. The in vitro assessment of the …

Epidemiological studies revealed that two-thirds of Alzheimer's disease (AD) patients are
women and the drop of sex steroid hormones after the menopause has been proposed to be …

The brain has high energy requirements to maintain neuronal activity. Consequently
impaired mitochondrial function will lead to disease. Normal aging is associated with several …

Our understanding of the intracrine (or local) regulation of estrogen and other steroid
synthesis and degradation expanded in the last decades, also thanks to recent …

Progress in understanding the role of monoamine neurotransmission in pathophysiology of
neuropsychiatric disorders was made after the discovery of the mechanisms of action of …

Current possibilities of Alzheimer's disease (AD) treatment are very limited and are based on
administration of cholinesterase inhibitors (donepezil, rivastigmine, galantamine) and/or N …

Mitochondrial enzyme 17β‐hydroxysteroid dehydrogenase type 10 (HSD10) is a potential
molecular target for treatment of mitochondrial‐related disorders such as Alzheimer's …