Advancing therapy for neuroblastoma
B Qiu, KK Matthay - Nature Reviews Clinical Oncology, 2022 - nature.com
Neuroblastomas are tumours of sympathetic origin, with a heterogeneous clinical course
ranging from localized or spontaneously regressing to widely metastatic disease …
ranging from localized or spontaneously regressing to widely metastatic disease …
[HTML][HTML] The evolution of risk classification for neuroblastoma
E Sokol, AV Desai - Children, 2019 - mdpi.com
Neuroblastoma is a tumor with great clinical heterogeneity. Patients in North America are
risk-stratified using a number of features including age at diagnosis, disease stage, tumor …
risk-stratified using a number of features including age at diagnosis, disease stage, tumor …
Revised neuroblastoma risk classification system: a report from the Children's Oncology Group
PURPOSE Treatment planning for children with neuroblastoma requires accurate
assessment of prognosis. The most recent Children's Oncology Group (COG) risk …
assessment of prognosis. The most recent Children's Oncology Group (COG) risk …
Frequency and Prognostic Impact of ALK Amplifications and Mutations in the European Neuroblastoma Study Group (SIOPEN) High-Risk Neuroblastoma Trial (HR …
A Bellini, U Pötschger, V Bernard… - Journal of Clinical …, 2021 - ascopubs.org
PURPOSE In neuroblastoma (NB), the ALK receptor tyrosine kinase can be constitutively
activated through activating point mutations or genomic amplification. We studied ALK …
activated through activating point mutations or genomic amplification. We studied ALK …
Tailoring therapy for children with neuroblastoma on the basis of risk group classification: past, present, and future
For children with neuroblastoma, the likelihood of cure varies widely according to age at
diagnosis, disease stage, and tumor biology. Treatments are tailored for children with this …
diagnosis, disease stage, and tumor biology. Treatments are tailored for children with this …
[HTML][HTML] PRIMAGE project: predictive in silico multiscale analytics to support childhood cancer personalised evaluation empowered by imaging biomarkers
L Martí-Bonmatí, Á Alberich-Bayarri… - European radiology …, 2020 - Springer
PRIMAGE is one of the largest and more ambitious research projects dealing with medical
imaging, artificial intelligence and cancer treatment in children. It is a 4-year European …
imaging, artificial intelligence and cancer treatment in children. It is a 4-year European …
The challenge of defining “ultra‐high‐risk” neuroblastoma
DA Morgenstern, R Bagatell, SL Cohn… - Pediatric Blood & …, 2019 - Wiley Online Library
Given the biological and clinical heterogeneity of neuroblastoma, risk stratification is vital to
determining appropriate treatment. Historically, most patients with high‐risk neuroblastoma …
determining appropriate treatment. Historically, most patients with high‐risk neuroblastoma …
A nomogram of clinical and biologic factors to predict survival in children newly diagnosed with high‐risk neuroblastoma: an International Neuroblastoma Risk Group …
Background Long‐term outcome remains poor for children with high‐risk neuroblastoma
(five‐year overall survival [OS]∼ 50%). Our objectives were to (a) identify prognostic …
(five‐year overall survival [OS]∼ 50%). Our objectives were to (a) identify prognostic …
[HTML][HTML] Immunotherapeutic strategies for neuroblastoma: present, past and future
Neuroblastoma is the most common extracranial pediatric solid tumor with a heterogeneous
clinical course, ranging from spontaneous regression to metastatic disease and death …
clinical course, ranging from spontaneous regression to metastatic disease and death …
Survival of Patients With Neuroblastoma After Assignment to Reduced Therapy Because of the 12-to 18-Month Change in Age Cutoff in Children's Oncology Group …
HG Bender, MS Irwin, MD Hogarty… - Journal of Clinical …, 2023 - ascopubs.org
PURPOSE In 2006, Children's Oncology Group (COG) reclassified subgroups of toddlers
diagnosed with neuroblastoma from high-risk to intermediate-risk, when the age cutoff for …
diagnosed with neuroblastoma from high-risk to intermediate-risk, when the age cutoff for …