Advancing therapy for neuroblastoma

B Qiu, KK Matthay - Nature Reviews Clinical Oncology, 2022 - nature.com
Neuroblastomas are tumours of sympathetic origin, with a heterogeneous clinical course
ranging from localized or spontaneously regressing to widely metastatic disease …

[HTML][HTML] The evolution of risk classification for neuroblastoma

E Sokol, AV Desai - Children, 2019 - mdpi.com
Neuroblastoma is a tumor with great clinical heterogeneity. Patients in North America are
risk-stratified using a number of features including age at diagnosis, disease stage, tumor …

Revised neuroblastoma risk classification system: a report from the Children's Oncology Group

MS Irwin, A Naranjo, FF Zhang, SL Cohn… - Journal of Clinical …, 2021 - ascopubs.org
PURPOSE Treatment planning for children with neuroblastoma requires accurate
assessment of prognosis. The most recent Children's Oncology Group (COG) risk …

Frequency and Prognostic Impact of ALK Amplifications and Mutations in the European Neuroblastoma Study Group (SIOPEN) High-Risk Neuroblastoma Trial (HR …

A Bellini, U Pötschger, V Bernard… - Journal of Clinical …, 2021 - ascopubs.org
PURPOSE In neuroblastoma (NB), the ALK receptor tyrosine kinase can be constitutively
activated through activating point mutations or genomic amplification. We studied ALK …

Tailoring therapy for children with neuroblastoma on the basis of risk group classification: past, present, and future

WH Liang, SM Federico, WB London… - JCO Clinical Cancer …, 2020 - ascopubs.org
For children with neuroblastoma, the likelihood of cure varies widely according to age at
diagnosis, disease stage, and tumor biology. Treatments are tailored for children with this …

[HTML][HTML] PRIMAGE project: predictive in silico multiscale analytics to support childhood cancer personalised evaluation empowered by imaging biomarkers

L Martí-Bonmatí, Á Alberich-Bayarri… - European radiology …, 2020 - Springer
PRIMAGE is one of the largest and more ambitious research projects dealing with medical
imaging, artificial intelligence and cancer treatment in children. It is a 4-year European …

The challenge of defining “ultra‐high‐risk” neuroblastoma

DA Morgenstern, R Bagatell, SL Cohn… - Pediatric Blood & …, 2019 - Wiley Online Library
Given the biological and clinical heterogeneity of neuroblastoma, risk stratification is vital to
determining appropriate treatment. Historically, most patients with high‐risk neuroblastoma …

A nomogram of clinical and biologic factors to predict survival in children newly diagnosed with high‐risk neuroblastoma: an International Neuroblastoma Risk Group …

L Moreno, D Guo, MS Irwin, F Berthold… - Pediatric Blood & …, 2021 - Wiley Online Library
Background Long‐term outcome remains poor for children with high‐risk neuroblastoma
(five‐year overall survival [OS]∼ 50%). Our objectives were to (a) identify prognostic …

[HTML][HTML] Immunotherapeutic strategies for neuroblastoma: present, past and future

F Morandi, F Sabatini, M Podestà, I Airoldi - Vaccines, 2021 - mdpi.com
Neuroblastoma is the most common extracranial pediatric solid tumor with a heterogeneous
clinical course, ranging from spontaneous regression to metastatic disease and death …

Survival of Patients With Neuroblastoma After Assignment to Reduced Therapy Because of the 12-to 18-Month Change in Age Cutoff in Children's Oncology Group …

HG Bender, MS Irwin, MD Hogarty… - Journal of Clinical …, 2023 - ascopubs.org
PURPOSE In 2006, Children's Oncology Group (COG) reclassified subgroups of toddlers
diagnosed with neuroblastoma from high-risk to intermediate-risk, when the age cutoff for …