Osteosarcoma is the most common primary malignant bone tumour in children and
adolescents. Due to micrometastatic spread, radical surgery alone rarely results in cure …

SF3B1 hotspot mutations are associated with a poor prognosis in several tumor types and
lead to global disruption of canonical splicing. Through synthetic lethal drug screens, we …

Bone tumours are difficult to diagnose and treat, as they are rare and over 60 different
subtypes are recognised. The emergence of next-generation sequencing has partly …

Purpose: Although multimodal chemotherapy has improved outcomes for patients with
osteosarcoma, the prognosis for patients who present with metastatic and/or recurrent …

Sarcoma is a rare cancer arising from soft tissue and bone and consists of more than 50
distinct subtypes. There is an increasing emphasis on understanding the cancer biology of …

Loss-of-function mutations in the RB1 tumour suppressor are key drivers in cancer, including
osteosarcoma. RB1 loss-of-function compromises genome-maintenance and hence could …

Bone tumors are a group of histologically diverse diseases that occur across all ages. Two of
the commonest, osteosarcoma (OS) and Ewing sarcoma (ES), are regarded as characteristic …

Simple Summary Triple negative breast cancer (TNBC) is an aggressive subtype of breast
cancer, with a high recurrence rate. Since treatment of BRCAmut TNBC patients with PARP …

Osteosarcoma is the most common bone cancer in adolescents and young adults, but it is a
rare cancer with no improvement in patient survival in the last four decades. The main …

Simple Summary Survival for many pediatric cancers has improved over recent decades.
However, for pediatric patients with solid tumors that fail to respond to standard therapies, or …