Retinitis pigmentosa (RP) is the most common cause of inherited blindness and is
characterised by the progressive loss of retinal photoreceptors. However, RP is a highly …

Background The retina, as part of the central nervous system (CNS) with limited capacity for
self-reparation and regeneration in mammals, is under cumulative environmental stress due …

Rod and cone photoreceptors are light-sensing cells in the human retina. Rods are
dominant in the peripheral retina, whereas cones are enriched in the macula, which is …

The cellular mechanisms underlying hereditary photoreceptor degeneration are still poorly
understood, a problem that is exacerbated by the enormous genetic heterogeneity of this …

Purpose Current sequencing strategies can genetically solve 55–60% of inherited retinal
degeneration (IRD) cases, despite recent progress in sequencing. This can partially be …

Receptor expression-enhancing proteins (REEPs) are an evolutionarily conserved protein
family that is pivotal to the structure and function of the endoplasmic reticulum (ER). The …

Introduction The mobilization and catabolism of lipid energy is a central function of
adipocytes that is under the control of the β-adrenergic signaling pathway, and defects in β …

Ocular diseases are a highly heterogeneous group of phenotypes, caused by a spectrum of
genetic variants and environmental factors that exhibit diverse clinical symptoms. As a result …

Spatiotemporal translational regulation plays a key role in determining cell fate and function.
Specifically, in neurons, local translation in dendrites is essential for synaptic plasticity and …

Purpose: To evaluate the impact of full-spectrum light-emitting diodes (LEDs) on albino
guinea pigs' retina and investigate the roles of short-wavelength opsin (S-opsin) and …