Pyrazoles containing thiophene, thienopyrimidine and thienotriazolopyrimidine as COX-2 selective inhibitors: Design, synthesis, in vivo anti-inflammatory activity …

MS El-Shoukrofy, HA Abd El Razik, OM AboulWafa… - Bioorganic …, 2019 - Elsevier
New thiophene and annulated thiophene pyrazole hybrids were synthesized and screened
for their in vitro COX-1/COX-2 enzymatic inhibition and in vivo anti-inflammatory activities. All …

Isolation of hesperetin-A flavonoid from Cordia sebestena flower extract through antioxidant assay guided method and its antibacterial, anticancer effect on cervical …

S Prakash, N Elavarasan, K Subashini… - Journal of Molecular …, 2020 - Elsevier
Since ancient time, plants serve as a treasure of effective drugs for cancer therapy. In the
present study, phytoconstituents and antioxidant activity of Cordia sebestena (C. sebestena) …

Benzoxazole derivatives as new generation of anti-breast cancer agents

AMME Omar, OM AboulWafa, MS El-Shoukrofy… - Bioorganic …, 2020 - Elsevier
New 2-substituted benzoxazole derivatives were synthesized and screened for their in vitro
anti-proliferative activities against MCF-7 and MDA-MB-231 cell lines. Compounds 4b, 4d …

[HTML][HTML] Factors Influencing the Production of Extracellular Polysaccharides by the Green Algae Dictyosphaerium chlorelloides and Their Isolation, Purification, and …

O Kronusová, P Kaštánek, G Koyun, F Kaštánek… - Microorganisms, 2022 - mdpi.com
The freshwater green microalgae, Dictyosphaerium chlorelloides (CCALA 330), has the
ability to produce extracellular polysaccharides (EPS). Conditions for optimum growth and …

Virtual screening of the natural antifoulants: In silico approach to screen lichen metabolites against marine biofoulers

R Subbaiyan, A Ganesan, S Dhanuskodi… - Environmental …, 2024 - Wiley Online Library
The present study aims to explore the inhibitory action of lichen metabolites against
important protein targets of marine fouling organisms using computational methods. Lichens …

Isolation and biological evaluation 7-hydroxy flavone from Avicennia officinalis L: insights from extensive in vitro, DFT, molecular docking and molecular dynamics …

A Parthiban, V Sachithanandam, P Lalitha… - Journal of …, 2023 - Taylor & Francis
The flavonoid based 7-hydroxy flavone (PubChem CID: 5281894; molecular formula:
C15H10O3) molecule has been isolated for the first time from the methanolic extract from the …

Marine derivatives prevent E6 protein of HPV: An in silico study for drug development

PM Quan, HBQ Anh, NTN Hang, DH Toan… - Regional Studies in …, 2022 - Elsevier
Cervical cancer (CC) is one of the most common cancers in women worldwide in which most
cases are diagnosed with the Human Papilloma Virus (HPV). At the present time, there is …

Structure-Based Discovery of Potential HPV E6 and EBNA1 Inhibitors: Implications for Cervical Cancer Treatment

E Broni, CN Ashley, M Velazquez, PO Sakyi, SK Kwofie… - Computation, 2024 - mdpi.com
Cervical cancer is the fourth most diagnosed cancer and the fourth leading cause of cancer
death in women globally. Its onset and progression have been attributed to high-risk human …

Potential suppression of multidrug-resistance-associated protein 1 by coumarin derivatives: an insight from molecular docking and MD simulation studies

P Shahpouri, H Mehralitabar, M Kheirabadi… - Journal of …, 2023 - Taylor & Francis
Human MRP1 protein plays a vital role in cancer multidrug resistance. Coumarins show
promising pharmacological properties. Virtual screening, ADMET, molecular docking and …

[PDF][PDF] Molecular Docking and Statistical Assessment of Macroalgae Halimeda Species against Marine Macro Fouler Mytilus galvoprovinces (4CN8)

R Prasanth, P Suresh Kumar - Int. J. Pharmaceut. Sci. Rev. Res, 2020 - researchgate.net
The purpose of this investigation was to study the inhibitory action of marine macro fouler by
macro algae using virtual screening studies in first time. Bioactive compounds from …