Metabolic dysfunction-associated steatotic liver disease (MASLD) affects one-third of the
global population. Understanding the metabolic pathways involved can provide insights into …

There is a lack of systematic research exploring cross-species variation in liver lobular
geometry and zonation patterns of critical drug-metabolizing enzymes, a knowledge gap …

Metabolic zonation refers to the spatial separation of metabolic functions along the
sinusoidal axes of the liver. This phenomenon forms the foundation for adjusting hepatic …

Motivation Systems biology aims to better understand living systems through mathematical
modelling of experimental and clinical data. A pervasive challenge in quantitative dynamical …

In dogs, Rhipicephalus linnaei transmits pathogens such as Ehrlichia canis, Babesia vogeli,
and Hepatozoon canis. The veterinary market has synthetic acaricides to ticks control. Esters …

To determine their involvement in the onset of the disease, we investigated the changing
levels of liver fibrosis-related proteins, namely, type-I collagen, α-smooth muscle actin (α …

Steatosis is a common liver disease characterized by the accumulation of lipid droplets in
cells. Precise and reliable fat droplet identification is essential for automatic steatosis …

Non-alcoholic fatty liver disease (NAFLD) affects nearly one third of the population
worldwide. Understanding metabolic pathways involved can provide insights into disease …

Multiscale modeling requires the coupling of models on different scales, often based on
different mathematical approaches and developed by different research teams. This poses …

Background: It was recently reported that periportal fibrosis in mice did affect the expression
of CYP proteins, a set of pericentrally located drug-metabolizing enzymes. This observation …