Impact of social relationships on Alzheimer's memory impairment: mechanistic studies
YH Hsiao, CH Chang, PW Gean - Journal of biomedical science, 2018 - Springer
Alzheimer's disease (AD) is characterized by progressive memory and neuronal loss
culminating in cognitive impairment that not only affects a person's living ability but also …
culminating in cognitive impairment that not only affects a person's living ability but also …
scGNN is a novel graph neural network framework for single-cell RNA-Seq analyses
Single-cell RNA-sequencing (scRNA-Seq) is widely used to reveal the heterogeneity and
dynamics of tissues, organisms, and complex diseases, but its analyses still suffer from …
dynamics of tissues, organisms, and complex diseases, but its analyses still suffer from …
[HTML][HTML] Fibroblast inflammatory priming determines regenerative versus fibrotic skin repair in reindeer
Adult mammalian skin wounds heal by forming fibrotic scars. We report that full-thickness
injuries of reindeer antler skin (velvet) regenerate, whereas back skin forms fibrotic scar …
injuries of reindeer antler skin (velvet) regenerate, whereas back skin forms fibrotic scar …
Lactate mediates the effects of exercise on learning and memory through SIRT1-dependent activation of hippocampal brain-derived neurotrophic factor (BDNF)
Exercise promotes learning and memory formation. These effects depend on increases in
hippocampal BDNF, a growth factor associated with cognitive improvement and the …
hippocampal BDNF, a growth factor associated with cognitive improvement and the …
Zinc-dependent deacetylases (HDACs) as potential targets for treating Alzheimer's disease
Y Li, S Lin, Z Gu, L Chen, B He - Bioorganic & Medicinal Chemistry Letters, 2022 - Elsevier
Alzheimer's disease (AD) as the most prevalent dementia type has become one of the
greatest threats to the health and life of the elder people worldwide. Although there has …
greatest threats to the health and life of the elder people worldwide. Although there has …
Single-cell RNA-seq of mouse olfactory bulb reveals cellular heterogeneity and activity-dependent molecular census of adult-born neurons
Cellular heterogeneity within the mammalian brain poses a challenge toward understanding
its complex functions. Within the olfactory bulb, odor information is processed by subtypes of …
its complex functions. Within the olfactory bulb, odor information is processed by subtypes of …
HDAC2 in primary sensory neurons constitutively restrains chronic pain by repressing α2δ-1 expression and associated NMDA receptor activity
α2δ-1 (encoded by the Cacna2d1 gene) is a newly discovered NMDA receptor-interacting
protein and is the therapeutic target of gabapentinoids (eg, gabapentin and pregabalin) …
protein and is the therapeutic target of gabapentinoids (eg, gabapentin and pregabalin) …
[11C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer's disease
Alzheimer's disease (AD) is characterized by the brain accumulation of amyloid-β and tau
proteins. A growing body of literature suggests that epigenetic dysregulations play a role in …
proteins. A growing body of literature suggests that epigenetic dysregulations play a role in …
Human iPSC-derived hippocampal spheroids: an innovative tool for stratifying Alzheimer disease patient-specific cellular phenotypes and developing therapies
Y Pomeshchik, O Klementieva, J Gil, I Martinsson… - Stem Cell Reports, 2020 - cell.com
The hippocampus is important for memory formation and is severely affected in the brain
with Alzheimer disease (AD). Our understanding of early pathogenic processes occurring in …
with Alzheimer disease (AD). Our understanding of early pathogenic processes occurring in …
The cis-regulatory effects of modern human-specific variants
The Neanderthal and Denisovan genomes enabled the discovery of sequences that differ
between modern and archaic humans, the majority of which are noncoding. However, our …
between modern and archaic humans, the majority of which are noncoding. However, our …