[HTML][HTML] Deriving physiological information from PET images: from SUV to compartmental modelling

A Bertoldo, G Rizzo, M Veronese - Clinical and Translational Imaging, 2014 - Springer
Positron emission tomography (PET) imaging has made it possible to detect the in vivo
concentration of positron-emitting compounds accurately and non-invasively. In order to …

Kinetic modeling of amyloid binding in humans using PET imaging and Pittsburgh Compound-B

JC Price, WE Klunk, BJ Lopresti, X Lu… - Journal of Cerebral …, 2005 - journals.sagepub.com
A valid quantitative imaging method for the measurement of amyloid deposition in humans
could improve Alzheimer's disease (AD) diagnosis and antiamyloid therapy assessment …

Spectral analysis of dynamic PET studies: a review of 20 years of method developments and applications

M Veronese, G Rizzo, A Bertoldo… - … methods in medicine, 2016 - Wiley Online Library
In Positron Emission Tomography (PET), spectral analysis (SA) allows the quantification of
dynamic data by relating the radioactivity measured by the scanner in time to the underlying …

Kinetic Modeling without Accounting for the Vascular Component Impairs the Quantification of [11C]PBR28 Brain PET Data

G Rizzo, M Veronese, M Tonietto… - Journal of Cerebral …, 2014 - journals.sagepub.com
The positron emission tomography radioligand [11C] PBR28 targets translocator protein (18
kDa)(TSPO) and is a potential marker of neuroinflammation.[11C] PBR28 binding is …

GABAA receptor availability is not altered in adults with autism spectrum disorder or in mouse models

J Horder, M Andersson, MA Mendez, N Singh… - Science translational …, 2018 - science.org
Preliminary studies have suggested that γ-aminobutyric acid type A (GABAA) receptors, and
potentially the GABAA α5 subtype, are deficient in autism spectrum disorder (ASD) …

Kinetic modelling of [11C]PBR28 for 18 kDa translocator protein PET data: A validation study of vascular modelling in the brain using XBD173 and tissue analysis

M Veronese, T Reis Marques… - Journal of Cerebral …, 2018 - journals.sagepub.com
The 18 kDa translocator protein (TSPO) is a marker of microglia activation in the central
nervous system and represents the main target of radiotracers for the in vivo quantification of …

Generalization of endothelial modelling of TSPO PET imaging: considerations on tracer affinities

G Rizzo, M Veronese, M Tonietto… - Journal of Cerebral …, 2019 - journals.sagepub.com
The 18 kDa translocator protein (TSPO) is a marker of microglia activation and the main
target of positron emission tomography (PET) ligands for neuroinflammation. Previous works …

Kinetic modeling of [18F]FDG in skeletal muscle by PET: a four-compartment five-rate-constant model

A Bertoldo, P Peltoniemi, V Oikonen… - American Journal …, 2001 - journals.physiology.org
Various modeling strategies have been developed to convert regional [18F]
fluorodeoxyglucose ([18F] FDG) concentration measured by positron emission tomography …

Validation of the semiquantitative static SUVR method for 18F-AV45 PET by pharmacokinetic modeling with an arterial input function

J Ottoy, J Verhaeghe, E Niemantsverdriet… - Journal of Nuclear …, 2017 - Soc Nuclear Med
Increased brain uptake of 18F-AV45 visualized by PET is a key biomarker for Alzheimer
disease (AD). The SUV ratio (SUVR) is widely used for quantification, but is subject to …

Interactions among glucose delivery, transport, and phosphorylation that underlie skeletal muscle insulin resistance in obesity and type 2 diabetes: studies with …

BH Goodpaster, A Bertoldo, JM Ng, K Azuma… - Diabetes, 2014 - Am Diabetes Assoc
Dynamic positron emission tomography (PET) imaging was performed using sequential
tracer injections ([15O] H2O,[11C] 3-O-methylglucose [3-OMG], and [18F] …