[HTML][HTML] The impact of oxidative stress and AKT pathway on cancer cell functions and its application to natural products

JP Shiau, YT Chuang, JY Tang, KH Yang, FR Chang… - Antioxidants, 2022 - mdpi.com
Oxidative stress and AKT serine-threonine kinase (AKT) are responsible for regulating
several cell functions of cancer cells. Several natural products modulate both oxidative …

Electrospun nanocarriers for delivering natural products for cancer therapy

R Mohammadinejad, VS Madamsetty, A Kumar… - Trends in Food Science …, 2021 - Elsevier
Background Electrospinning has provided an excellent opportunity to develop nano-sized
fibers with a broad range of applications, including nano-drug delivery systems for the …

[HTML][HTML] Efficacy of SPG-ODN 1826 nanovehicles in inducing M1 phenotype through TLR-9 activation in murine alveolar J774A. 1 cells: Plausible nano …

MF Aldawsari, A Alalaiwe, ES Khafagy… - International Journal of …, 2021 - mdpi.com
Alveolar macrophages are the first line of defense against intruding pathogens and play a
critical role in cancer immunology. The Toll-like receptor (TLR) family mediates an important …

[HTML][HTML] In Vitro Evaluation of Antioxidant, Anticancer, and Anti-Inflammatory Activities of Ethanolic Leaf Extract of Adenium obesum

A Alshehri, A Ahmad, RK Tiwari, I Ahmad… - Frontiers in …, 2022 - frontiersin.org
Adenium obesum commonly known as “desert rose” belongs to the family Apopcynaceae
and has previously been reported for its anti-influenza, antimicrobial, and cytotoxic efficacies …

[HTML][HTML] Ganetespib with methotrexate acts synergistically to impede NF-κB/p65 signaling in human lung cancer A549 cells

G Subaiea, SMD Rizvi, HKS Yadav, T Al Hagbani… - Pharmaceuticals, 2023 - mdpi.com
Among the various types of cancer, lung cancer accounts for the highest number of fatalities
across the globe. A combination of different cancer chemotherapeutics is regarded as an …

High therapeutic efficacy of 5‐Fluorouracil‐loaded exosomes against colon cancer cells

R Shekh, A Ahmad, RK Tiwari, M Saeed… - Chemical Biology & …, 2023 - Wiley Online Library
The successful chemotherapeutic regime required for the clinical management of different
cancers largely depends on the efficient drug delivery within the cancer cells. Exosomes …

[HTML][HTML] Ethanolic Extract of Artemisia vulgaris Leaf Promotes Apoptotic Cell Death in Non-Small-Cell Lung Carcinoma A549 Cells through Inhibition of the Wnt …

RK Tiwari, A Ahmad, AF Khan, LA Al-Keridis, M Saeed… - Metabolites, 2023 - mdpi.com
The Wnt signaling pathway is reported to be associated with lung cancer progression,
metastasis and drug resistance, and thus it is an important therapeutic target for lung cancer …

[HTML][HTML] Aloe-emodin exhibits growth-suppressive effects on androgen-independent human prostate cancer DU145 cells via inhibiting the Wnt/β-catenin signaling …

T Hussain, A Alafnan, IA Almazni, N Helmi… - Frontiers in …, 2024 - frontiersin.org
At the molecular level, several developmental signaling pathways, such as Wnt/β-catenin,
have been associated with the initiation and subsequent progression of prostate …

[HTML][HTML] Carvacrol instigates intrinsic and extrinsic apoptosis with abrogation of cell cycle progression in cervical cancer cells: Inhibition of Hedgehog/GLI signaling …

A Ahmad, RK Tiwari, M Saeed, H Al-Amrah… - Frontiers in …, 2023 - frontiersin.org
Recent times have seen a strong surge in therapeutically targeting the hedgehog (HH)/GLI
signaling pathway in cervical cancer. HH signaling pathway is reported to be a crucial …

Pinostrobin suppresses the proliferation of lung carcinoma cells by abrogating the cell cycle progression through the inhibition of Notch signaling pathway

RK Tiwari, A Ahmad, MS Khan, SD Shahanawaz… - South African Journal of …, 2022 - Elsevier
Pinostrobin (PN) is a dietary bioflavonoid naturally found in numerous medicinal plants.
Even though the anticancer potential of flavonoids has been studied; however the molecular …