Adiponectin regulation and function

H Fang, RL Judd - Comprehensive Physiology, 2011 - Wiley Online Library
Adipose tissue is now recognized as an important endocrine organ, capable of secreting a
large number of endocrine factors which regulate a wide variety of physiological functions …

Adipokines: a link between obesity and dementia?

AJ Kiliaan, IAC Arnoldussen, DR Gustafson - The Lancet Neurology, 2014 - thelancet.com
Being overweight or obese, as measured with body-mass index or central adiposity (waist
circumference), and the trajectory of body-mass index over the life course have been …

Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake

N Kubota, W Yano, T Kubota, T Yamauchi, S Itoh… - Cell metabolism, 2007 - cell.com
Adiponectin has been shown to stimulate fatty acid oxidation and enhance insulin sensitivity
through the activation of AMP-activated protein kinase (AMPK) in the peripheral tissues. The …

Metabolic dysfunction in Alzheimer's disease and related neurodegenerative disorders

H Cai, W Cong, S Ji, S Rothman… - Current Alzheimer …, 2012 - ingentaconnect.com
Alzheimer's disease and other related neurodegenerative diseases are highly debilitating
disorders that affect millions of people worldwide. Efforts towards developing effective …

The complex interactions between obesity, metabolism and the brain

RM Uranga, JN Keller - Frontiers in neuroscience, 2019 - frontiersin.org
Obesity is increasing at unprecedented levels globally, and the overall impact of obesity on
the various organ systems of the body is only beginning to be fully appreciated. Because of …

Insulin resistance as a link between amyloid-beta and tau pathologies in Alzheimer's disease

RJ Mullins, TC Diehl, CW Chia… - Frontiers in aging …, 2017 - frontiersin.org
Current hypotheses and theories regarding the pathogenesis of Alzheimer's disease (AD)
heavily implicate brain insulin resistance (IR) as a key factor. Despite the many well …

Adiponectin receptor signalling in the brain

J Thundyil, D Pavlovski, CG Sobey… - British journal of …, 2012 - Wiley Online Library
Adiponectin is an important adipocyte‐derived hormone that regulates metabolism of lipids
and glucose, and its receptors (AdipoR1, AdipoR2, T‐cadherin) appear to exert actions in …

Obesity and dementia: adipokines interact with the brain

IAC Arnoldussen, AJ Kiliaan, DR Gustafson - European …, 2014 - Elsevier
Obesity is a pandemic and a serious global health concern. Obesity is a risk factor for
multiple conditions and contributes to multi-morbidities, resulting in increased health costs …

Mechanisms linking obesity to hypertension

JAN Dorresteijn, FLJ Visseren, W Spiering - Obesity Reviews, 2012 - Wiley Online Library
Obesity‐related hypertension is increasingly recognized as a distinct hypertensive
phenotype requiring a modified approach to diagnosis and management. In this review …

Mechanisms of adiponectin action in fertility: an overview from gametogenesis to gestation in humans and animal models in normal and pathological conditions

A Barbe, A Bongrani, N Mellouk, A Estienne… - International journal of …, 2019 - mdpi.com
Adiponectin is the most abundant plasma adipokine. It mainly derives from white adipose
tissue and plays a key role in the control of energy metabolism thanks to its insulin …