[HTML][HTML] Targeting p53 pathways: mechanisms, structures, and advances in therapy
H Wang, M Guo, H Wei, Y Chen - Signal transduction and targeted …, 2023 - nature.com
The TP53 tumor suppressor is the most frequently altered gene in human cancers, and has
been a major focus of oncology research. The p53 protein is a transcription factor that can …
been a major focus of oncology research. The p53 protein is a transcription factor that can …
[HTML][HTML] Nanomaterials for cancer therapy: current progress and perspectives
Cancer is a disease with complex pathological process. Current chemotherapy faces
problems such as lack of specificity, cytotoxicity, induction of multi-drug resistance and stem …
problems such as lack of specificity, cytotoxicity, induction of multi-drug resistance and stem …
A compendium of mutational cancer driver genes
A fundamental goal in cancer research is to understand the mechanisms of cell
transformation. This is key to developing more efficient cancer detection methods and …
transformation. This is key to developing more efficient cancer detection methods and …
[HTML][HTML] Integrated analysis of TP53 gene and pathway alterations in the cancer genome atlas
The TP53 tumor suppressor gene is frequently mutated in human cancers. An analysis of
five data platforms in 10,225 patient samples from 32 cancers reported by The Cancer …
five data platforms in 10,225 patient samples from 32 cancers reported by The Cancer …
p53, cancer and the immune response
J Blagih, MD Buck, KH Vousden - Journal of cell science, 2020 - journals.biologists.com
The importance of cancer-cell-autonomous functions of the tumour suppressor p53
(encoded by TP53) has been established in many studies, but it is now clear that the p53 …
(encoded by TP53) has been established in many studies, but it is now clear that the p53 …
Adaptations to endurance and strength training
The capacity for human exercise performance can be enhanced with prolonged exercise
training, whether it is endurance-or strength-based. The ability to adapt through exercise …
training, whether it is endurance-or strength-based. The ability to adapt through exercise …
Phase 1 Trial of ALRN-6924, a Dual Inhibitor of MDMX and MDM2, in Patients with Solid Tumors and Lymphomas Bearing Wild-type TP53
Purpose: We describe the first-in-human dose-escalation trial for ALRN-6924, a stabilized,
cell-permeating peptide that disrupts p53 inhibition by mouse double minute 2 (MDM2) and …
cell-permeating peptide that disrupts p53 inhibition by mouse double minute 2 (MDM2) and …
Stem-cell aging and pathways to precancer evolution
CHM Jamieson, IL Weissman - New England Journal of Medicine, 2023 - Mass Medical Soc
Stem-Cell Aging and Pathways to Precancer Evolution | New England Journal of Medicine Skip
to main content The New England Journal of Medicine homepage Advanced Search SEARCH …
to main content The New England Journal of Medicine homepage Advanced Search SEARCH …
Cancer as a metabolic disease: implications for novel therapeutics
TN Seyfried, RE Flores, AM Poff… - …, 2014 - academic.oup.com
Emerging evidence indicates that cancer is primarily a metabolic disease involving
disturbances in energy production through respiration and fermentation. The genomic …
disturbances in energy production through respiration and fermentation. The genomic …
[HTML][HTML] LncRNA-miRNA axis in tumor progression and therapy response: An emphasis on molecular interactions and therapeutic interventions
Epigenetic factors are critical regulators of biological and pathological mechanisms and they
could interact with different molecular pathways. Targeting epigenetic factors has been an …
could interact with different molecular pathways. Targeting epigenetic factors has been an …