Psoriasis and cardiovascular disease risk in European and East Asian populations: evidence from meta-analysis and Mendelian randomization analysis
L Zhang, Y Wang, L Qiu, J Wu - BMC medicine, 2022 - Springer
Background Psoriasis has been linked to cardiovascular disease (CVD), including coronary
artery disease (CAD), myocardial infarction (MI), and heart failure (HF). However, available …
artery disease (CAD), myocardial infarction (MI), and heart failure (HF). However, available …
Etiologic puzzle of coronary artery disease: how important is genetic component?
In the modern era, coronary artery disease (CAD) has become the most common form of
heart disease and, due to the severity of its clinical manifestations and its acute …
heart disease and, due to the severity of its clinical manifestations and its acute …
Genetic drivers of heterogeneity in type 2 diabetes pathophysiology
Abstract Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse
pathophysiological processes, and molecular mechanisms that are often specific to cell …
pathophysiological processes, and molecular mechanisms that are often specific to cell …
Integration of Multiple‐Omics Data to Analyze the Population‐Specific Differences for Coronary Artery Disease
Significant differences may exist among different descents, but the current studies are mainly
based on European populations. In the present study, we analyzed the population‐specific …
based on European populations. In the present study, we analyzed the population‐specific …
Ancestry-specific polygenic risk scores are risk enhancers for clinical cardiovascular disease assessments
Clinical implementation of new prediction models requires evaluation of their utility in a
broad range of intended use populations. Here we develop and validate ancestry-specific …
broad range of intended use populations. Here we develop and validate ancestry-specific …
Genome-wide association studies on coronary artery disease: A systematic review and implications for populations of different ancestries
Background Cardiovascular diseases are some of the leading causes of death worldwide,
with coronary artery disease leading as one of the primary causes of mortality in both the …
with coronary artery disease leading as one of the primary causes of mortality in both the …
Myoglobin in Brown Adipose Tissue: A Multifaceted Player in Thermogenesis
Brown adipose tissue (BAT) plays an important role in energy homeostasis by generating
heat from chemical energy via uncoupled oxidative phosphorylation. Besides its high …
heat from chemical energy via uncoupled oxidative phosphorylation. Besides its high …
Polygenic risk score associates with atherosclerotic plaque characteristics at autopsy
A Cornelissen, NV Gadhoke, K Ryan… - … , and vascular biology, 2024 - Am Heart Assoc
BACKGROUND: Polygenic risk scores (PRSs) for coronary artery disease (CAD) potentially
improve cardiovascular risk prediction. However, their relationship with histopathologic …
improve cardiovascular risk prediction. However, their relationship with histopathologic …
[HTML][HTML] Multi-ancestry genome-wide study in> 2.5 million individuals reveals heterogeneity in mechanistic pathways of type 2 diabetes and complications
Abstract Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse
pathophysiological processes. To characterise the genetic contribution to these processes …
pathophysiological processes. To characterise the genetic contribution to these processes …
Integration of biomarker polygenic risk score improves prediction of coronary heart disease
There are several established biomarkers for coronary heart disease (CHD), including blood
pressure, cholesterol, and lipoproteins. It is of high interest to determine how a combined …
pressure, cholesterol, and lipoproteins. It is of high interest to determine how a combined …