[HTML][HTML] Polymer-and lipid-based nanocarriers for ocular drug delivery: current status and future perspectives

H Han, S Li, M Xu, Y Zhong, W Fan, J Xu, T Zhou… - Advanced Drug Delivery …, 2023 - Elsevier
Ocular diseases seriously affect patients' vision and life quality, with a global morbidity of
over 43 million blindness. However, efficient drug delivery to treat ocular diseases …

An insight on ophthalmic drug delivery systems: focus on polymeric biomaterials-based carriers

M Shafiq, M Rafique, Y Cui, L Pan, CW Do… - Journal of Controlled …, 2023 - Elsevier
Presently, different types of eye diseases, such as glaucoma, myopia, infection, and dry eyes
are treated with topical eye drops. However, due to ocular surface barriers, eye drops …

Multifaceted roles of pollen in the management of cancer

T Kolipaka, P Khairnar, V Phatale, G Pandey… - International Journal of …, 2023 - Elsevier
Oral drug delivery of microparticles demonstrates shortcomings like aggregation, decreased
loading capacity and batch-to-batch variation, which limits its scale-up. Later, porous …

Emerging trends in nano-based antidiabetic therapeutics: a path to effective diabetes management

R Sharma, SJ Borah, S Kumar, A Gupta, V Kumari… - Materials …, 2023 - pubs.rsc.org
Diabetes mellitus is characterized by altered blood sugar homeostasis. Diabetic mortality
rates are escalating in developed countries by the day. Currently, no effective treatment and …

Chitosan-coated bovine serum albumin nanoparticles for topical tetrandrine delivery in glaucoma: in vitro and in vivo assessment

SES Radwan, RM El-Moslemany, RA Mehanna… - Drug Delivery, 2022 - Taylor & Francis
Glaucoma is one of the leading causes of blindness. Therapies available suffer from several
drawbacks including low bioavailability, repeated administration and poor patient …

Hyaluronic acid: Its versatile use in ocular drug delivery with a specific focus on hyaluronic acid-based polyelectrolyte complexes

S Casey-Power, R Ryan, G Behl, P McLoughlin… - Pharmaceutics, 2022 - mdpi.com
Extensive research is currently being conducted into novel ocular drug delivery systems
(ODDS) that are capable of surpassing the limitations associated with conventional …

Overcoming Treatment Challenges in Posterior Segment Diseases with Biodegradable Nano-Based Drug Delivery Systems

KY Wu, M Joly-Chevrier, D Akbar, SD Tran - Pharmaceutics, 2023 - mdpi.com
Posterior segment eye diseases present a challenge in treatment due to the complex
structures in the eye that serve as robust static and dynamic barriers, limiting the penetration …

Preparation, physicochemical, and retinal anti-angiogenic evaluation of poloxamer hydrogel containing dexamethasone/avastin-loaded chitosan-N-acetyl-L-cysteine …

SL Taheri, M Rezazadeh, F Hassanzadeh… - International Journal of …, 2022 - Elsevier
This study was meant to describe a Poloxamer hydrogel combining Chitosan-N-acetyl-L-
cysteine (CNAC) nanoparticles to increase loading and sustained intravitreal administration …

Recent advances of ocular drug delivery systems: prominence of ocular implants for chronic eye diseases

M Mostafa, A Al Fatease, RG Alany, H Abdelkader - Pharmaceutics, 2023 - mdpi.com
Chronic ocular diseases can seriously impact the eyes and could potentially result in
blindness or serious vision loss. According to the most recent data from the WHO, there are …

Emerging treatment strategies for diabetes mellitus and associated complications: an update

V Mishra, P Nayak, M Sharma, A Albutti, ASS Alwashmi… - Pharmaceutics, 2021 - mdpi.com
The occurrence of diabetes mellitus (DM) is increasing rapidly at an accelerating rate
worldwide. The status of diabetes has changed over the last three generations; whereas …