One hundred years ago, Ramón y Cajal, considered by many as the founder of modern
neuroscience, stated that neurons of the adult central nervous system (CNS) are incapable …

The peripheral nervous system has retained through evolution the capacity to repair and
regenerate after assault from a variety of physical, chemical, or biological pathogens …

Axonal injury results in regenerative success or failure, depending on whether the axon lies
in the peripheral or the CNS, respectively. The present study addresses whether epigenetic …

α2δ-1 (encoded by the Cacna2d1 gene) is a newly discovered NMDA receptor-interacting
protein and is the therapeutic target of gabapentinoids (eg, gabapentin and pregabalin) …

The interruption of spinal circuitry following spinal cord injury (SCI) disrupts neural activity
and is followed by a failure to mount an effective regenerative response resulting in …

Overcoming the restricted axonal regenerative ability that limits functional repair following a
central nervous system injury remains a challenge. Here we report a regenerative paradigm …

Regeneration after injury occurs in axons that lie in the peripheral nervous system but fails in
the central nervous system, thereby limiting functional recovery. Differences in axonal …

Neural injury in mammals often leads to persistent functional deficits as spontaneous repair
in the peripheral nervous system (PNS) is often incomplete, while endogenous repair …

Peripheral nervous system (PNS) neurons support axon regeneration into adulthood,
whereas central nervous system (CNS) neurons lose regenerative ability after development …

The peripheral nervous system (PNS) has a remarkable regenerative capacity in
comparison to the central nervous system (CNS), a phenomenon that is impaired during …