Xenobiotic-induced liver injury is a clinically important etiology of hepatic disease that, if not
recognized, can lead to hepatic failure. In this article we discuss the mechanisms of …

Glucuronidation is a major metabolic pathway for a large number of drugs in humans.
Conjugation of drugs and other chemicals with glucuronic acid is catalyzed by the multigene …

Aromatic amines are well known as occupational carcinogens and are found in cooked
foods, tobacco smoke, synthetic fuels, and agricultural chemicals. For the primary …

The wide variations in urinary bladder and colo-rectal cancer incidence in humans have
been attributed in part to metabolic factors associated with exposure to carcinogenic …

Objectives To investigate the CYP1A2 genotype-phenotype relationship and to compare
CYP1A2 genetic polymorphisms and enzyme activity in terms of the effect of smoking and …

This review updates and evaluates the currently available information regarding the
pharmacokinetics, metabolism and interactions of the acid pump inhibitors omeprazole …

Drug interactions have always been a major concern in medicine for clinicians and patients.
Inhibition and induction of cytochrome P450 (CYP) enzymes are probably the most common …

Metabolic food-drug interactions occur when the consumption of a particular food modulates
the activity of a drug-metabolising enzyme system, resulting in an alteration of the …

The metabolism of the carcinogenic mycotoxin aflatoxin B1 (AFB1) was examined in
microsomes derived from human lymphoblastoid cell lines expressing transfected CYP1A2 …

Food intake exerts a complex influence on the bioavailability of drugs. It may interfere not
only with tablet disintegration, drug dissolution and drug transit through the gastrointestinal …