Glioma, the most common primary malignant tumor in the central nervous system (CNS),
lacks effective treatments, and> 60% of cases are glioblastoma (GBM), the most aggressive …

Metabolic rewiring of cancer cells is one of the hallmarks of cancer. As a consequence, the
metabolic landscape of the tumour microenvironment (TME) differs compared to …

Glioblastoma (GBM), an aggressive brain malignancy with a cellular hierarchy dominated by
GBM stem cells (GSCs), evades antitumor immunity through mechanisms that remain …

Lactylation, a recently identified post-translational modification, has initially been linked to
gene transcription regulation through epigenetic mechanisms. However, its role in …

Lactylation, a newly identified post-translational modification, is uncertain in its implication in
triple-negative breast cancer (TNBC). In this study, we analyzed 60 TNBC samples using …

The blood–brain barrier (BBB) caused limited drug accumulation and programmed death-
ligand 1 (PD-L1) compromised immunosuppressive microenvironment are bottlenecks in …

Lactate, an important metabolic product, provides energy to neural cells during energy
depletion or high demand and acts as a signaling molecule in the central nervous system …

Background High-altitude cerebral edema (HACE) is considered an end-stage acute
mountain sickness (AMS) that typically occurs in people after rapid ascent to 2500 m or …

Lactylation, a recently identified form of protein post‐translational modification (PTM), has
emerged as a key player in cancer biology. The Warburg effect, a hallmark of tumour …

Background To investigate the impact of preoperative glycosylated hemoglobin A1C
(HbA1c) among patients following curative‐intent resection of nonfunctional …