Inositol pyrophosphates (IPPs) are present in organisms ranging from plants, slime moulds
and fungi to mammals. Distinct classes of kinases generate different forms of energetic …

In mammals, a family of three inositol hexakisphosphate kinases (IP6Ks) synthesizes the
inositol pyrophosphate 5-IP7 from IP6. Genetic deletion of Ip6k1 protects mice from high fat …

The interactions between mathematics and physiology have a long and illustrious history, of
which the study of calcium signalling is but a small chapter. Nevertheless, for those involved …

There is a paucity of information concerning the developmental neurotoxicity (DNT) hazard
posed by industrial and environmental chemicals. New testing approaches will most likely …

Dietary flavonoids inhibit certain protein kinases and phospholipid kinases by competing for
their ATP-binding sites. These nucleotide pockets have structural elements that are well …

Objective Obesity and type 2 diabetes (T2D) lead to various life-threatening diseases such
as coronary heart disease, stroke, osteoarthritis, asthma, and neurodegeneration. Therefore …

Obesity and nonalcoholic fatty liver disease (NAFLD) are global health concerns, and thus,
drugs for the long-term treatment of these diseases are urgently needed. We previously …

To help define the molecular basis of cellular signalling cascades, and their biological
functions, there is considerable value in utilizing a high-quality chemical 'probe'that has a …

Neuronal growth factor (NGF) induces neurodifferentiationofPC12cellsintocholiner…
neurons-like cells. It was shown that intracellular Ca2+ ions participate in regulation of the …

Epidermal growth factor [EGF] mediated stimulation of its receptor in endothelial cell [EC] is
accompanied by phosphorylation of the EGF-receptor [EGFR] and activation of …