A novel, potent, and selective antitumor agent, namely (E)-3-phenyl-1-(2-pyridinyl)-2-propen-
1-one 4, 4-dimethyl-3-thiosemicarbazone (PPP44mT), and its analogues were synthesized …

The development of cancers is often linked to the alteration of essential redox processes,
and therefore, oxidoreductases involved in such mechanisms can be considered as …

The cellular defense system against exogenous substances makes therapeutics inefficient
as intracellular glutathione (GSH) exhibits an astounding antioxidant activity in scavenging …

Anthracycline antibiotics, eg, doxorubicin, daunomycin, and other anthraquinones, are an
important family of antitumor agents widely used in chemotherapy, which is currently the …

To overcome the resistance of tumour cells to cis-diaminedichloroplatinum (II)(cisplatin,
DDP), we designed and synthesised platinum (II) complexes with copper coordination active …

Ascorbic acid is a multifaceted compound that can perform both antioxidant and pro-oxidant
activities in the redox reactions induced by transition metal ions, so its role in nature and …

The mechanisms of stereoselectivity of the interaction of chiral drugs with active sites of
enzymes and cell receptors attract significant attention. The first reason is the difference in …

Background/Objectives: Some specific anthraquinone derivatives (AQs) are known to be
used widely as effective chemotherapeutic agents in the treatment of cancer. However, their …

Crocin is a unique water-soluble carotenoid found in crocus and gardenia flowers. Crocin
has been shown to have a variety of pharmacological activities, such as antioxidant, anti …

肿瘤大剂量维生素C (HVC) 治疗本质上是一种代谢调节, 通过促氧化应激, 表观遗传修饰,
免疫和氧感应调控等机制调节肿瘤和机体代谢重编程而治疗肿瘤. 中医药具有多靶点 …