Safety pharmacology (SP) is an essential part of the drug development process that aims to
identify and predict adverse effects prior to clinical trials. SP studies are described in the …

Reactions to acute stressors are critical for survival. Yet, the challenges of assessing
underlying physiological processes in the field limit our understanding of how variation in …

Background Significant cardiorespiratory events can be triggered in preterm infants as part
of laryngeal chemoreflexes (LCRs) and esophageal reflexes (ERs). We previously showed …

With recent developments in electronics and progress on micro/nano/biotechnologies,
implantable biosystems have become more common. These systems help to improve the …

Current knowledge suggests that laryngeal chemoreflexes (LCR) are involved in the
occurrence of certain neonatal apneas/bradycardias, especially in the preterm newborn …

Background In preterm infants, the time from initiation to full oral feeding can take weeks,
which represents a very worrisome problem in neonatal medicine. Although current …

The use of prolonged respiratory support under the form of high-flow nasal cannula (HFNC)
or nasal continuous positive airway pressure (nCPAP) is frequent in newborn infants …

Newborn infants with respiratory difficulties frequently require nasal respiratory support such
as nasal continuous positive airway pressure (nCPAP) or high-flow nasal cannulae (HFNC) …

Current knowledge suggests that, to be successful, oral feeding in preterm infants should be
initiated as soon as possible, often at an age where immature respiration still requires …

Sucking, swallowing and breathing are dynamic motor behaviors. Breathing displays
features of chaos-like dynamics, in particular nonlinearity and complexity, which take their …